Reference code: | PT/FB/BL-2020-333.05 |
Location: | BF-GMS
|
Title:
| Psilocybin enhances insightfulness in meditation: A perspective on the global topology of brain imaging during meditation
|
Publication year: | 2024
|
URL:
| https://doi.org/10.1038/s41598-024-55726-x
|
Abstract/Results: | ABSTRACT:
In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before and after a five-day psilocybin-assisted meditation retreat using a recently established approach, based on the Mapper algorithm from topological data analysis. After generating subject-specific maps for two groups (psilocybin vs. placebo, 18 subjects/group) of experienced meditators, organizational principles were uncovered using graph topological tools, including the optimal transport (OT) distance, a geometrically rich measure of similarity between brain activity patterns. This revealed characteristics of the topology (i.e. shape) in space (i.e. abstract space of voxels) and time dimension of whole-brain activity patterns during different styles of meditation and psilocybin-induced alterations. Most interestingly, we found that (psilocybin-induced) positive derealization, which fosters insightfulness specifically when accompanied by enhanced open-monitoring meditation, was linked to the OT distance between open-monitoring and resting state. Our findings suggest that enhanced meta-awareness through meditation practice in experienced meditators combined with potential psilocybin-induced positive alterations in perception mediate insightfulness. Together, these findings provide a novel perspective on meditation and psychedelics that may reveal potential novel brain markers for positive synergistic effects between mindfulness practices and psilocybin.
|
Accessibility: | Document exists in file
|
Language:
| eng
|
Author:
| Berit, S.
|
Secondary author(s):
| Meling, D., Hirsch-Hoffmann, M., Michels, L., Kometer, M., Smigielski, L., Dornbierer, D., Seifritz, E., Vollenweider, F., Scheidegger, M.
|
Document type:
| Article
|
Number of reproductions:
| 3
|
Reference:
| Singer, B., Meling, D., Hirsch-Hoffmann, M., Michels, L., Kometer, M., Smigielski, L., Dornbierer, D., Seifritz, E., Vollenweider, F. X., & Scheidegger, M. (2024). Psilocybin enhances insightfulness in meditation: A perspective on the global topology of brain imaging during meditation. Scientific reports, 14(1), 7211. https://doi.org/10.1038/s41598-024-55726-x
|
2-year Impact Factor: | 3.80|2023
|
Impact factor notes: | Impact factor not available yet for 2024
|
Times cited: | 2|2025-02-19
|
Indexed document: | Yes
|
Quartile: | Q1
|
Keywords: | Life-threatening cancer / Mindfulness / Experience / Interventions / Depression / Anxiety / States
|
Psilocybin enhances insightfulness in meditation: A perspective on the global topology of brain imaging during meditation |