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Volitional modulation of primary visual cortex activity requires the basal ganglia

2018

BIAL Foundation Archive
- BIAL Grants
  - 2014 Grants
    - 413 - The role of dopamine in behavioral exploration and action selection
      - Volitional modulation of primary visual cortex activity requires the basal ganglia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2014
Location:	BF-GMS
Title:	2014 Grants
Start date:	2015-01

Reference code:	PT/FB/BL-2014-413
Location:	BF-GMS
Title:	413 - The role of dopamine in behavioral exploration and action selection
Duration:	2015-03 - 2018-06
Researcher(s):	Aaron Christopher Koralek
Institution(s):	Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Progress report Final report Articles
Language:	eng
Author:	Koralek, A. C.
Number of reproductions:	1
Keywords:	Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code:	PT/FB/BL-2014-413.02
Location:	BF-GMS
Title:	Volitional modulation of primary visual cortex activity requires the basal ganglia
Publication year:	2018
URL:	https://www.sciencedirect.com/science/article/pii/S089662731830076X#ack0010
Abstract/Results:	ABSTRACT: Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Neely, R.
Secondary author(s):	Koralek, A., Athalye, V. R., Costa, R. M., Carmena, J. M.
Document type:	Article
Number of reproductions:	1
Reference:	Neely, R., Koralek, A., Athalye, V. R., Costa, R. M., & Carmena, J. M. (2018). Volitional modulation of primary visual cortex activity requires the basal ganglia. Neuron, 97(6),1356–1368.e4. https://doi.org/10.1016/j.neuron.2018.01.051
2-year Impact Factor:	14.403\|2018
Times cited:	31\|2025-02-11
Indexed document:	Yes
Quartile:	Q1
Keywords:	Brain-machine interface / Visual cortex / Striatum / Learning / Optogenetics / Instrumental conditioning