YGGYWeb - BIAL Foundation Archives

History

Processing, please wait...

Database

Filter year from

Language

Country

Base:

BIAL Foundation

Search:

DE:"Striatum"

Results

from

found.

View

Selection

Description

Type

Title

Begin

End

Document

Task specific contribution of the human striatum to perceptual-motor skill learning

2011

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 003 - The neural structures involved in procedural memory
      - Task specific contribution of the human striatum to perceptual-motor skill learning

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-003
Location:	Arquivo PCA - Pasta 8/2002
Title:	003 - The neural structures involved in procedural memory
Duration:	2003-11 - 2006-11
Researcher(s):	Sara Cavaco, Alexandre Lemos de Castro Caldas, Steven Anderson
Institution(s):	Centro de Estudos Egas Moniz, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Cavaco, S.
Secondary author(s):	Castro-Caldas, A., Anderson, S.
Number of reproductions:	1
Keywords:	Psychophysiology / Biopsychological problems / Diseases/Injuries / Brain dysfunction / Cognitive processes / Learning

Reference code:	PT/FB/BL-2002-003.03
Location:	Arquivo PCA - Pasta 8/2002
Title:	Task specific contribution of the human striatum to perceptual-motor skill learning
Publication year:	2011
URL:	http://www.tandfonline.com/doi/abs/10.1080/13803395.2010.493144?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.Utz4rNGp0q4
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=325&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: Acquisition of new perceptual-motor skills depends on multiple brain areas, including the striatum. However, the specific contribution of each structure to this type of learning is still poorly understood. Focusing on the striatum, we proposed (a) to replicate the finding of impaired rotary pursuit (RP) and preserved mirror tracing (MT) in Huntington's disease (HD); and (b) to further explore this putative learning dissociation with other human models of striatal dysfunction (i.e., Parkinson's disease and focal vascular damage) and two new paradigms (i.e., Geometric Figures, GF, and Control Stick, CS) of skill learning. Regardless of the etiology, participants with damage to the striatum showed impaired learning of visuomotor tracking skills (i.e., RP and GF), whereas the ability to learn skills that require motor adaptation (i.e., MT and CS) was not affected. These results suggest a task-specific involvement of the striatum in the early stages of skill learning.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Cavaco, S.
Secondary author(s):	Anderson, S., Correia, H., Magalhães, M., Pereira, C., Tuna, A., Taipa, R., Pinto, P., Pinto, C., Cruz, R., Lima, A., Castro-Caldas, A., Martins da Silva, A., Damásio, H.
Document type:	Article
Number of reproductions:	1
Reference:	Cavaco, S., Anderson, S., Correia, M., Magalhães, M., Pereira, C., Tuna, A. . . . Damásio, H. (2011). Task specific contribution of the human striatum to perceptual-motor skill learning. Journal of Clinical and Experimental Neuropsychology, 33(1), 51-62. https://doi.org/10.1080/13803395.2010.493144
2-year Impact Factor:	2.133\|2011
Times cited:	20\|2025-02-10
Indexed document:	Yes
Quartile:	Q2
Keywords:	Nondeclarative memory / Skill learning / Striatum / Huntington's disease / Parkinson's disease

Document

The neural structures involved in procedural memory

2008

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 003 - The neural structures involved in procedural memory
      - The neural structures involved in procedural memory

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-003
Location:	Arquivo PCA - Pasta 8/2002
Title:	003 - The neural structures involved in procedural memory
Duration:	2003-11 - 2006-11
Researcher(s):	Sara Cavaco, Alexandre Lemos de Castro Caldas, Steven Anderson
Institution(s):	Centro de Estudos Egas Moniz, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Cavaco, S.
Secondary author(s):	Castro-Caldas, A., Anderson, S.
Number of reproductions:	1
Keywords:	Psychophysiology / Biopsychological problems / Diseases/Injuries / Brain dysfunction / Cognitive processes / Learning

Reference code:	PT/FB/BL-2002-003.09
Location:	Arquivo PCA - Pasta 8/2002
Title:	The neural structures involved in procedural memory
Publication year:	2008
URL:	http://www.bial.com/imagem/Actas_7Simp.pdf
Accessibility:	Document does not exist in file
Language:	eng
Author:	Cavaco, S.
Secondary author(s):	Castro-Caldas, A., Anderson, A.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Cavaco, S., Castro-Caldas, A., & Anderson, A. (2008). The neural structures involved in procedural memory. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document:	No
Keywords:	Procedural memory / Skill learning / Striatum
Novo ficheiro

Document

Chronic stress causes frontostriatal reorganization and affects decision-making

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
      - Chronic stress causes frontostriatal reorganization and affects decision-making

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-134
Location:	Arquivo PCA - Pasta 11/2006
Title:	134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration:	2007-01 - 2010-02
Researcher(s):	Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s):	Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:	1
Keywords:	Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code:	PT/FB/BL-2006-134.02
Location:	Arquivo PCA - Pasta 11/2006
Title:	Chronic stress causes frontostriatal reorganization and affects decision-making
Publication year:	2009
URL:	http://www.sciencemag.org/content/325/5940/621.abstract
Abstract/Results:	ABSTRACT: The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dias-Ferreira, E.
Secondary author(s):	Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:	Article
Number of reproductions:	1
Reference:	Dias-Ferreira, E., Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., ... Sousa, N. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325(5940), 621-625. https://doi.org/10.1126/science.1171203
2-year Impact Factor:	29.747\|2009
Times cited:	639\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychophysiology / Stress / Chronic stress / Decision-making / Striatum

Document

Chronic stress causes corticostriatal reorganization and affects decision-making

2008

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
      - Chronic stress causes corticostriatal reorganization and affects decision-making

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-134
Location:	Arquivo PCA - Pasta 11/2006
Title:	134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration:	2007-01 - 2010-02
Researcher(s):	Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s):	Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:	1
Keywords:	Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code:	PT/FB/BL-2006-134.03
Location:	Arquivo PCA - Pasta 11/2006
Title:	Chronic stress causes corticostriatal reorganization and affects decision-making
Publication year:	2008
URL:	http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=f8fdb142-74dd-4797-95a8-b588d7016d51&cKey=78c9c63c-a5d0-4448-adcc-3a016fdd759d&mKey=%7bAFEA068D-D012-4520-8E42-10E4D1AF7944%7d
Abstract/Results:	ABSTRACT: Maladaptive responses to stress depend on the intensity and duration of stressors; chronic exposure to stressful events has been shown to predispose to several conditions raging from neuropsychiatric disorders to everyday lapses of attention. Several reports implicate chronic stress in executive function impairment. In this study, we investigated the impact that chronic stress (21 days of chronic unpredictable stress (CUS)) would have on corticostriatal circuits, which are critical for decision making. By 3-D analysis of Golgi stained neurons, we confirmed our previous results indicating that exposure to chronic stress results in dramatic reductions in the total length of apical dendrites in the pyramidal neurons in layer II/III of the prelimbic (PL) and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC). Interestingly, the impact of chronic stress on the striatum was not uniform: while we found a significant increase in the total length of dendrites in the medium spiny neurons (MSNs) of the dorsolateral striatum (DLS, or sensorimotor striatum), there was a trend to a decrease in the total length of dendrites in MSNs of the dorsomedial striatum (DMS). Taken together these data suggest that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal networks. These different circuits have been implicated in different types of actions: the PL cortex and the DMS have been implicated in goal-directed actions, which depend on the relation between the execution of the action and potential outcomes, and on the expected value of those outcomes. In contrast, the DLS has been implicated in the formation of habits, which are insensitive to changes in outcome value and changes in the contingency between action and outcome. Therefore, it is conceivable that chronic stress could play a role in decision-making driving the behavior control from actions to habits. In order to test this hypothesis, rats submitted to chronic stress were trained to press a lever for specific outcomes and subsequently tested for their action-outcome behavior. Using two different behavioral assays, we found that responses from animals submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Taken together, our data suggests that chronic stress causes a dramatic structural reorganization of corticostriatal circuits, which results in impaired goal-directed behavior and increased predisposition for habit formation.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dias-Ferreira, E.
Secondary author(s):	Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Dias-Ferreira, E., Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., & Sousa, N. (2008). Chronic stress causes corticostriatal reorganization and affects decision-making. Program No. 195.5/UU54. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
Indexed document:	No
Keywords:	Chronic stress / Decision-making / Striatum / Corticosteroids

Document

Chronic stress affects decision-making strategies: Structural and physiological correlates

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
      - Chronic stress affects decision-making strategies: Structural and physiological correlates

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-134
Location:	Arquivo PCA - Pasta 11/2006
Title:	134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration:	2007-01 - 2010-02
Researcher(s):	Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s):	Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:	1
Keywords:	Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code:	PT/FB/BL-2006-134.04
Location:	Arquivo PCA - Pasta 11/2006
Title:	Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year:	2009
URL:	http://www.frontiersin.org/10.3389/conf.neuro.01.2009.11.008/event_abstract
Abstract/Results:	ABSTRACT: The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats and mice submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we found that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). In addition, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dias-Ferreira, E.
Secondary author(s):	Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. https://doi.org/10.3389/conf.neuro.01.2009.11.008
Indexed document:	No
Keywords:	Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

Document

Chronic stress affects decision-making strategies: Structural and physiological correlates

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
      - Chronic stress affects decision-making strategies: Structural and physiological correlates

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-134
Location:	Arquivo PCA - Pasta 11/2006
Title:	134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration:	2007-01 - 2010-02
Researcher(s):	Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s):	Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:	1
Keywords:	Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code:	PT/FB/BL-2006-134.06
Location:	Arquivo PCA - Pasta 11/2006
Title:	Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year:	2009
URL:	http://www.frontiersin.org/10.3389/conf.neuro.06.2009.03.348/39/Computational_and_systemsneu/all_events/event_abstract
Abstract/Results:	ABSTRACT: The stress response is vital to maintain homeostasis. However, chronic exposure to stress can trigger maladaptive response and predispose to conditions ranging from neuropsychiatric disorders to everyday lapses of attention. Even though previous reports have implicated chronic stress in executive function impairment, a conceivable role in decision-making processes remains to be clarified. Competing corticostriatal circuits are thought to control heterogeneous decision strategies: while the prelimbic (PL) cortex and the dorsomedial striatum (DMS, or associative striatum) have been implicated in goal-directed actions, the dorsolateral striatum (DLS, or sensorimotor striatum) has been implicated in automatic or habitual choices. Here we show that chronic stress impairs the decision-making process, predisposing to habitual behavior in detriment of goal-directed strategies. Using two different criteria to test for action-outcome behavior in a lever pressing task, we found that responses from rats and mice submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Furthermore, we found that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal circuits. Whereas chronic exposure to stress resulted in selective atrophy of pyramidal neurons in layer II/III of the PL and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC) and in medium spiny neurons (MSNs) of the DMS, it triggered an opposite effect in MSNs of the DLS. To determine if this structural reorganization of frontostriatal circuits has functional consequences, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits underlie changes in neural activity in these circuits that could explain the bias from goal-directed towards habitual behavior observed in stressed subjects.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dias-Ferreira, E.
Secondary author(s):	Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. https://doi.org/10.3389/conf.neuro.01.2009.11.008
Indexed document:	No
Keywords:	Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

Document

The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
      - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-134
Location:	Arquivo PCA - Pasta 11/2006
Title:	134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration:	2007-01 - 2010-02
Researcher(s):	Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s):	Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:	1
Keywords:	Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code:	PT/FB/BL-2006-134.07
Location:	Arquivo PCA - Pasta 11/2006
Title:	The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Publication year:	2010
URL:	http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results:	ABSTRACT: The ability to shift between different behavioral strategies is necessary for appropriate decision-making. In this project, we investigated if chronic stress biases decision-making strategies, affecting the ability of stressed rats to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats, and now confirmed for mice, submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we demonstrated that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). Therefore, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit. In conclusion, the results obtained throughout this project demonstrate that chronic stress influences decision-making processes, through changes in the structure and activity of corticostriatal networks.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Sousa, N.
Secondary author(s):	Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Sousa, N., Costa, R. M., Dias-Ferreira, E., Cerqueira, J., & Teixeira, P. (2010). The role of stress in cortico-basal ganglia loop processing and instrumental conditioning. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (pp. 231-232). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Corticosteroids / Decision-making / Plasticity / Striatum / Multielectrode recordings
The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

Document

Sleep and Emotional Functions

2014

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
      - Sleep and Emotional Functions

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-225
Location:	Arquivo PCA - Pasta 12/2012
Title:	225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration:	2013-10 - 2016-02
Researcher(s):	Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s):	Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final report Article
Language:	eng
Author:	Schwartz, S.
Secondary author(s):	Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code:	PT/FB/BL-2012-225.02
Location:	Arquivo PCA - Pasta 12/2012
Title:	Sleep and Emotional Functions
Publication year:	2014
URL:	http://link.springer.com/chapter/10.1007%2F7854_2013_271
Abstract/Results:	ABSTRACT: In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Perogamvros, L.
Secondary author(s):	Schwartz, S.
Document type:	Article
Number of reproductions:	1
Reference:	Perogamvros, L., & Schwartz, S. (2014). Sleep and Emotional Functions. Current Topics in Behavioral Neurosciences, 25, 411-431. https://doi.org/10.1007/7854_2013_271
2-year Impact Factor:	N/A
Times cited:	N/A
Indexed document:	Yes
Quartile:	N/A
Keywords:	Sleep / Sleep deprivation / Dreaming / Emotion / Cognition / Reward / Sexual function / Creativity / Memory consolidation / Brain development / Amygdala / Prefrontal cortex / Hippocampus / Ventral tegmental area / Striatum / Nucleus accumbens / Dopamine / Limbic / Mesolimbic
Sleep and Emotional Functions

Document

Striatal dynamics explain duration judgments

2015

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 188 - Embodied cognition: the nature of time encoding in the brain?
      - Striatal dynamics explain duration judgments

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-188
Location:	Arquivo PCA - Pasta 17/2012
Title:	188 - Embodied cognition: the nature of time encoding in the brain?
Duration:	2013-06 - 2016-09
Researcher(s):	Joseph James Paton, Tiago Monteiro, Thiago Gouvêa, Sofia Soares
Institution(s):	Fundação Champalimaud, Lisboa (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final report Article
Language:	eng
Author:	Paton, J.
Secondary author(s):	Monteiro, T., Gouvêa, T., Soares, S.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Cognition / Learning

Reference code:	PT/FB/BL-2012-188.03
Location:	Arquivo PCA - Pasta 17/2012
Title:	Striatal dynamics explain duration judgments
Publication year:	2015
URL:	https://elifesciences.org/content/4/e11386
Abstract/Results:	ABSTRACT: The striatum is an input structure of the basal ganglia implicated in several time-dependent functions including reinforcement learning, decision making, and interval timing. To determine whether striatal ensembles drive subjects' judgments of duration, we manipulated and recorded from striatal neurons in rats performing a duration categorization psychophysical task. We found that the dynamics of striatal neurons predicted duration judgments, and that simultaneously recorded ensembles could judge duration as well as the animal. Furthermore, striatal neurons were necessary for duration judgments, as muscimol infusions produced a specific impairment in animals' duration sensitivity. Lastly, we show that time as encoded by striatal populations ran faster or slower when rats judged a duration as longer or shorter, respectively. These results demonstrate that the speed with which striatal population state changes supports the fundamental ability of animals to judge the passage of time.
Accessibility:	Document exists in file
Language:	eng
Author:	Gouvêa, T.
Secondary author(s):	Monteiro, T., Motiwala, A., Soares, S., Machens, C., Paton, J.
Document type:	Article
Number of reproductions:	1
Reference:	Gouvêa, T., Monteiro, T., Motiwala, A., Soares, S., Machens, C., & Paton, J. (2015). Striatal dynamics explain duration judgments. eLife, 4:e11386. https://doi.org/10.7554/eLife.11386
2-year Impact Factor:	8.282\|2015
Times cited:	120\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Interval timing / Neural dynamics / Neuroscience / Population code / Rat / Striatum
Striatal dynamics explain duration judgments

Document

Volitional modulation of primary visual cortex activity requires the basal ganglia

2018

BIAL Foundation Archive
- BIAL Grants
  - 2014 Grants
    - 413 - The role of dopamine in behavioral exploration and action selection
      - Volitional modulation of primary visual cortex activity requires the basal ganglia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2014
Location:	BF-GMS
Title:	2014 Grants
Start date:	2015-01

Reference code:	PT/FB/BL-2014-413
Location:	BF-GMS
Title:	413 - The role of dopamine in behavioral exploration and action selection
Duration:	2015-03 - 2018-06
Researcher(s):	Aaron Christopher Koralek
Institution(s):	Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents:	Contents: Application form Correspondence Progress report Final report Articles
Language:	eng
Author:	Koralek, A. C.
Number of reproductions:	1
Keywords:	Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code:	PT/FB/BL-2014-413.02
Location:	BF-GMS
Title:	Volitional modulation of primary visual cortex activity requires the basal ganglia
Publication year:	2018
URL:	https://www.sciencedirect.com/science/article/pii/S089662731830076X#ack0010
Abstract/Results:	ABSTRACT: Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Neely, R.
Secondary author(s):	Koralek, A., Athalye, V. R., Costa, R. M., Carmena, J. M.
Document type:	Article
Number of reproductions:	1
Reference:	Neely, R., Koralek, A., Athalye, V. R., Costa, R. M., & Carmena, J. M. (2018). Volitional modulation of primary visual cortex activity requires the basal ganglia. Neuron, 97(6),1356–1368.e4. https://doi.org/10.1016/j.neuron.2018.01.051
2-year Impact Factor:	14.403\|2018
Times cited:	31\|2025-02-11
Indexed document:	Yes
Quartile:	Q1
Keywords:	Brain-machine interface / Visual cortex / Striatum / Learning / Optogenetics / Instrumental conditioning

Document

Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

2020

BIAL Foundation Archive
- BIAL Grants
  - 2018 Grants
    - 252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
      - Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2018
Location:	BF-GMS
Title:	2018 Grants
Start date:	2019-01

Reference code:	PT/FB/BL-2018-252
Location:	BF-GMS
Title:	252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration:	2019-10 - 2022-09
Researcher(s):	Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s):	Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents:	Contents: Application form Correspondence Research Funding Agreement Progress report Final report Articles
Language:	eng
Author:	Castelo-Branco, M.
Secondary author(s):	Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:	3
Keywords:	Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code:	PT/FB/BL-2018-252.03
Location:	BF-GMS
Title:	Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues
Publication year:	2020
URL:	https://www.frontiersin.org/articles/10.3389/fnins.2020.00678/full
Abstract/Results:	ABSTRACT: “Wanting”, a component of reward processing, is a motivational property that guides decision making in goal-oriented behavior. This includes behavior aiming at supporting relational bonds, even at the group level. Accordingly, group belongingness works as this motivational property, which is fundamentally different from romantic or maternal love. While primary rewards (or learned associations, such as money) have been largely used to study the conceptual framework associated with “wanting,” other cues triggering behavior, such as passionate motives, are less well-studied. We investigated the neural correlates of value estimation of a passion-driven incentive in neuropsychologically defined football fans. We asked the participants (n = 57) to compute the value of football tickets (the cues that trigger passionate behavior in this “tribal love” context). The trials were all different, comprising tickets for different matches. The participants had no restrictions on the amount to be introduced. This enabled a parametric functional magnetic resonance imaging design based on the explicit estimated value given by the participants in a trial-by-trial approach. Using a whole-brain approach (to prevent biased focus on value-related regions), only the activity in the ventral caudate and left anterior insula showed a critical relationship with the reported value. Higher normalized values led to more activity in the striatum and left insula. The parametric map shows that these regions encode the magnitude of incentive by indexing self-relevant value. Other regions were involved in value computation, such as the ventromedial prefrontal cortex, lateral orbitofrontal cortex, and dorsolateral prefrontal cortex, but did not exhibit parametric patterns. The involvement of the nucleus accumbens in value estimation was only found in region of interest -based analysis, which emphasizes the role of the ventral caudate for the presently studied social “reinforcer” cue.
Accessibility:	Document exists in file
Language:	eng
Author:	Duarte, I. C.
Secondary author(s):	Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M.
Document type:	Article
Number of reproductions:	3
Reference:	Duarte, I. C., Coelho, G., Brito-Costa, S., Cayolla, R., Afonso, S., Castelo-Branco, M. (2020). Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues. Frontiers in Neuroscience, 14: 678. https://doi.org/10.3389/fnins.2020.00678
2-year Impact Factor:	4.677\|2020
Times cited:	5\|2025-02-14
Indexed document:	Yes
Quartile:	Q2
Keywords:	Reward / Decision making / Ingroup / Striatum / Insula / Caudate
Ventral caudate and anterior insula recruitment during value estimation of passionate rewarding cues

Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

2022

BIAL Foundation Archive
- BIAL Grants
  - 2020 Grants
    - 175 - The role of nucleus accumbens in the perception of natural rewards
      - Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2020
Location:	BF-GMS
Title:	2020 Grants
Start date:	2021-01

Reference code:	PT/FB/BL-2020-175
Location:	BF-GMS
Title:	175 - The role of nucleus accumbens in the perception of natural rewards
Duration:	2021-06 - 2025-01
Researcher(s):	Carina Cunha, Ana João Rodrigues, Nivaldo Vasconcelos, Rodrigo Oliveira, Bárbara Coimbra, Ana Verónica Domingues, Gabriela Martins
Institution(s):	Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal); Zuckerman Institute, Columbia University, New York City (USA)
Contents:	Contents: Application form Correspondence Research Funding Agreement Progress report Final report Articles
Language:	eng
Author:	Cunha, C.
Secondary author(s):	Rodrigues, A. J., Vasconcelos, N., Oliveira, R., Coimbra, B., Domingues, A. V., Martins, G.
Number of reproductions:	1
Keywords:	Nucleus accumbens / Reward / Calcium imaging / Optogenetics / Psychophysiology

Reference code:	PT/FB/BL-2020-175.02
Location:	BF-GMS
Title:	Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Publication year:	2022
URL:	https://www.sciencedirect.com/science/article/pii/S2211124722001012
Abstract/Results:	The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
Accessibility:	Document exists in file
Language:	eng
Author:	Soares-Cunha, C.
Secondary author(s):	Domingues. A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:	Article
Number of reproductions:	1
Reference:	Soares-Cunha, C., Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N. & Rodrigues, A. J. (2022). Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports, 38, 7 https://doi.org/10.1016/j.celrep.2022.110380
2-year Impact Factor:	8.800\|2022
Times cited:	30\|2025-02-17
Indexed document:	Yes
Quartile:	Q1
Keywords:	Nucleus accumbens / Ventral pallidum / Reward / Motivation / Medium spiny neurons / D2 / Striatum
Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Document

Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

2022

BIAL Foundation Archive
- BIAL Grants
  - 2016 Grants
    - 030 - Exploring the neural basis of motivation
      - Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2016
Location:	BF-GMS
Title:	2016 Grants
Start date:	2017-01

Reference code:	PT/FB/BL-2016-030
Location:	BF-GMS
Title:	030 - Exploring the neural basis of motivation
Duration:	2017-01 - 2020-03
Researcher(s):	Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s):	Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents:	Contents: Application form Correspondence Research Funding Agreement Progress report Final report Articles
Author:	Rodrigues, A. J.
Secondary author(s):	Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:	1
Keywords:	Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code:	PT/FB/BL-2016-030.11
Location:	BF-GMS
Title:	Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Publication year:	2022
URL:	https://www.sciencedirect.com/science/article/pii/S2211124722001012
Abstract/Results:	The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
Accessibility:	Document exists in file
Language:	eng
Author:	Soares-Cunha, C.
Secondary author(s):	Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:	Article-d
Number of reproductions:	1
Reference:	Soares-Cunha, C., Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N. & Rodrigues, A. J. (2022). Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports, 38, 7. https://doi.org/10.1016/j.celrep.2022.110380
2-year Impact Factor:	8.800\|2022
Times cited:	30\|2025-02-17
Indexed document:	Yes
Quartile:	Q1
Keywords:	Nucleus accumbens / Ventral pallidum / Reward / Motivation / Medium spiny neurons / D2 / Striatum
Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior