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Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation

2025

BIAL Foundation Archive
- BIAL Grants
  - 2020 Grants
    - 099 - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
      - Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2020
Location:	BF-GMS
Title:	2020 Grants
Start date:	2021-01

Reference code:	PT/FB/BL-2020-099
Location:	BF-GMS
Title:	099 - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
Duration:	2021-03 - 2024-02
Researcher(s):	Matthew Sacchet, Diego Pizzagalli, Remko van Lutterveld, Marta Bianciardi
Institution(s):	Center for Depression, Anxiety, and Stress Research - CDASR, McLean Hospital, Belmont (USA)
Contents:	Contents: Application form Correspondence Research Funding Agreement Progress report Final report Articles
Language:	eng
Author:	Sacchet, M.
Secondary author(s):	Pizzagalli, D., van Lutterveld, R., Bianciardi, M.
Number of reproductions:	3
Keywords:	Advanced meditation / Enlightenment / Neuroimaging / Mindfulness meditation / Psychophysiology and Parapsychology

Reference code:	PT/FB/BL-2020-099.19
Location:	BF-GMS
Title:	Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation
Publication year:	2025
URL:	https://doi.org/10.1016/j.neuroimage.2024.120968
Abstract/Results:	ABSTRACT: The stages of insight (SoI) are a series of psychological realizations experienced through advanced investigative insight meditation (AIIM). SoI provide a powerful structured framework of AIIM for understanding and evaluating insight-based meditative development through changes in perception, experiences of self, cognition, and emotional processing. Yet, the neurophenomenology of SoI remains unstudied due to methodological difficulties, rarity of suitable advanced meditation practitioners, and dominant research emphasis on attention-based meditative practices. We investigated the neurophenomenology of SoI in an intensively sampled adept meditator case study (4 hr 7T fMRI collected in 26 runs with concurrent phenomenology) who performed SoI and rated specific aspects of experience immediately thereafter. Linear mixed models and correlations were used to examine relations among the cortex, subcortex, brainstem, and cerebellum, and SoI phenomenology. We identified distinctive whole-brain activity patterns associated with specific SoI, and that were different from two non-meditative control states. SoI consistently deactivated regions implicated in self-related processing, including the medial prefrontal cortex and temporal poles, while activating regions associated with awareness and perception, including the parietal and visual cortices, caudate, several brainstem nuclei, and cerebellum. Patterns of brain activity related to affective processing and SoI phenomenology were also identified. Our study presents the first neurophenomenological evidence that SoI shifts and deconstructs self-related perception and conceptualization, and increases general awareness and perceptual sensitivity and acuity. Our study provides SoI as a foundation for investigative, and advanced meditation in particular.
Copyright/Reproduction:	Document exists in file
Language:	eng
Author:	Yang, W. F. Z.
Secondary author(s):	Chowdhury, A., Sparby, T., Sacchet, M. D.
Document type:	Article
Number of reproductions:	3
Reference:	Yang, W. F. Z., Chowdhury, A., Sparby, T., & Sacchet, M. D. (2025). Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation. NeuroImage, 305, 120968. https://doi.org/10.1016/j.neuroimage.2024.120968
2-year Impact Factor:	4.7\|2023
Impact factor notes:	Impact factor not available yet for 2025
Times cited:	0\|2025-02-20
Indexed document:	Yes
Quartile:	Q1
Keywords:	Advanced meditation / Neurophenomenology / Stages of insight / 7T functional magnetic resonance imaging (fMRI) / Brainstem / Cerebellum
Deconstructing the self and reshaping perceptions: An intensive whole-brain 7T MRI case study of the stages of insight during advanced investigative insight meditation