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Brain function, creativity, paranormal ideation and risk for psychosis

2006

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 090 - Brain function, creativity, paranormal ideation and risk for psychosis
      - Brain function, creativity, paranormal ideation and risk for psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-090
Location:	Arquivo PCA - Pasta 5/2002
Title:	090 - Brain function, creativity, paranormal ideation and risk for psychosis
Duration:	2003-03 - 2005-04
Researcher(s):	Alexander Sumich, Michael Brammer, Dominic Ffytch
Institution(s):	Brain Image Analysis Unit, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report Diskette (Reseacrch Bursary 02-03, Alex Sumich: Brain function, creativity, paranormal ideation and risk for psychosis - BIAL)
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Brammer, M., Ffytch, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2002-090.02
Location:	Arquivo PCA - Pasta 5/2002
Title:	Brain function, creativity, paranormal ideation and risk for psychosis
Publication year:	2006
URL:	http://www.bial.com/imagem/1178809516livroactas.pdf
Accessibility:	Document does not exist in file
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Brammer, M., Ffytch, D.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Sumich, A., Brammer, M., & Ffytch, D. (2006). Brain function, creativity, paranormal ideation and risk for psychosis. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 6th Symposium of Fundação Bial (p. 254). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Psychophysiology / Psychosis / Paranormal ideation / Schizophrenia
Novo ficheiro

Document

Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

2012

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.03
Location:	Arquivo PCA - Pasta 17/2006
Title:	Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?
Publication year:	2012
URL:	http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8443224
Abstract/Results:	ABSTRACT: BACKGROUND: Both involuntary dyskinetic movements and psychotic-like experiences (PLEs) are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic activity in the striatum. The present study compared dyskinetic movement abnormalities displayed by children with multiple antecedents of schizophrenia (ASz), including speech and/or motor developmental lags or problems, internalising/externalising problems in the clinical range, and PLEs, with those displayed by children with no antecedents (noASz). METHOD: The sample included 21 ASz and 31 noASz children, aged 9-12 years old. None had taken psychotropic medication or had relatives with psychosis. The antecedents of schizophrenia were assessed using questionnaires completed by children and caregivers. A trained rater, blind to group status, coded dyskinetic movement abnormalities using a validated tool from videotapes of interviews with the children. RESULTS: ASz children reported, on average, 'certain experience' of 2.5 PLEs, while noASz children, by definition, reported none. The ASz children, as compared with noASz children, displayed significantly more dyskinetic movement abnormalities in total, and in the facial and the upper-body regions, after controlling for sex and age. Receiver operator characteristics analyses yielded high area under the curve values for the total score (0.94), facial score (0.91) and upper-body score (0.86), indicating that these scores distinguished between the ASz and noASz children with great accuracy. CONCLUSIONS: Brief questionnaires identified children with multiple antecedents of schizophrenia who displayed significantly more involuntary dyskinetic movement abnormalities than children without antecedents. The presence of PLEs and dyskinesias could reflect early disruption of striatal dopamine circuits.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	MacManus, D.
Secondary author(s):	Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., Hodgins, S.
Document type:	Article
Number of reproductions:	1
Reference:	MacManus, D., Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., & Hodgins, S. (2012). Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia? Psychological Medicine, 42(1), 99-109. https://doi.org/10.1017/S0033291711001085
2-year Impact Factor:	5.587\|2012
Times cited:	27\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Antecedents / Dopamine / Dyskinesia / Psychosis / Risk factors
Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

Document

Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.04
Location:	Arquivo PCA - Pasta 17/2006
Title:	Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia
Publication year:	2010
URL:	http://www.sciencedirect.com/science/article/pii/S0920996410013551
Abstract/Results:	ABSTRACT: BACKGROUND: We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia. METHODS: Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition. RESULTS: Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size=0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p<0.05). The severity of problems on each of the individual antecedents comprising the antecedent triad did not relate strongly to performance on the neurocognitive domains. CONCLUSIONS: Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms. Longitudinal follow-up is necessary to determine the extent to which poorer neurocognitive performance is specific to those who develop schizophrenia.
Accessibility:	Document exists in file (previous version submitted for publication)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Cullen, A. E.
Secondary author(s):	Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., Laurens, K. R.
Document type:	Article
Number of reproductions:	1
Reference:	Cullen, A. E., Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., & Laurens, K. R. (2010). Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia. Schizophrenia Research, 121(1-3), 15-23. https://doi.org/10.1016/j.schres.2010.05.034
2-year Impact Factor:	4.374\|2010
Times cited:	34\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	High-risk / Psychosis / Intelligence / Executive function / Memory / Scholastic achievement
Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia

Document

Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.05
Location:	Arquivo PCA - Pasta 17/2006
Title:	Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia
Publication year:	2010
URL:	http://www.sciencedirect.com/science/article/pii/S0006322309009081
Abstract/Results:	ABSTRACT: BACKGROUND: Intervention aimed at preventing schizophrenia may be most effective if targeted at specific, but modifiable, functional impairments that present during childhood. We have developed a novel method of screening community samples aged 9 to 12 years to identify children who present a triad of putative antecedents of schizophrenia (ASz), defined as 1) speech and/or motor development lags/problems; 2) internalizing, externalizing, and/or peer-relationship problems in the clinical range; and 3) psychotic-like experiences. This study examined whether ASz children display brain function abnormalities during error processing that are similar to those exhibited by adults with schizophrenia. METHODS: Twenty-two ASz children and 26 typically developing (TD) children with no antecedents of schizophrenia completed an error-inducing Go/NoGo task during event-related potential recording. Group differences were examined in the amplitude and latency of four event-related potential components: the initial error-related negativity (ERN) and later error-positivity (Pe) elicited on false-alarm responses to NoGo trials, and the corresponding initial correct response negativity (CRN) and later correct response positivity (Pc) elicited during processing of correct responses to Go trials. RESULTS: Relative to TD children, ASz children were characterized by reduced ERN amplitude but unaffected CRN, Pe, and Pc amplitudes. No group differences were observed in the latency of any component. CONCLUSIONS: Children presenting a triad of putative antecedents of schizophrenia show error-processing dysfunction mimicking that observed in adults with schizophrenia using the same Go/NoGo paradigm. The ASz children displayed specific early error-processing deficits rather than a generalized deficit in self-monitoring.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Mould, G. L., West, S. A., Schoenberg, P. L., Murray, R., Taylor, E.
Document type:	Article
Number of reproductions:	1
Reference:	Laurens, K. R., Hodgins, S., Mould, G. L., West, S. A., Schoenberg, P. L., Murray, R., & Taylor, E. (2010). Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia. Biological Psychiatry, 67(3), 238-245. https://doi.org/10.1016/j.biopsych.2009.07.030
2-year Impact Factor:	8.674\|2010
Times cited:	47\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Child psychopathology / Error positivity / Error-related negativity / Event-related potential (ERP) / High-risk / Psychosis
Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia

Document

Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom

2008

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.06
Location:	Arquivo PCA - Pasta 17/2006
Title:	Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom
Publication year:	2008
URL:	http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1927620
Abstract/Results:	ABSTRACT: BACKGROUND: The incidence of schizophrenia and the prevalence of psychotic symptoms in the general adult population are elevated in migrant and ethnic minority groups relative to host populations. These increases are particularly prominent among African-Caribbean migrants to the UK. This study examined the associations of ethnicity and migrant status with a triad of putative antecedents of schizophrenia in a UK community sample of children aged 9–12 years. The antecedent triad comprised: (i) psychotic-like experiences; (ii) a speech and/or motor developmental delay or abnormality; and (iii) a social, emotional or behavioural problem. METHOD: Children (n=595) and their primary caregivers, recruited via schools and general practitioners in southeast London, completed questionnaires. Four indices of risk were examined for associations with ethnicity and migrant status: (i) certain experience of at least one psychotic-like experience; (ii) severity of psychotic-like experiences (total psychotic-like experience score); (iii) experience of the antecedent triad; and (iv) severity of antecedent triad experiences (triad score). RESULTS: African-Caribbean children, as compared to white British children, experienced greater risk on all four indices. There were trends for South Asian and Oriental children to present lowered risk on several indices, relative to white British children. Migration status was unrelated to any risk index. CONCLUSION: Prevalence of the putative antecedents of schizophrenia is greater among children of African-Caribbean origin living in the UK than among white British children. This parallels the increased incidence of schizophrenia and elevated prevalence of psychotic symptoms among adults of African-Caribbean origin.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	West, S. A., Murray, R., Hodgins, S.
Document type:	Article
Number of reproductions:	1
Reference:	Laurens, K. R., West, S. A., Murray, R., & Hodgins, S. (2008). Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom. Psychological Medicine, 38(8), 1103-1112. https://doi.org/10.1017/S0033291707001845
2-year Impact Factor:	4.718\|2008
Times cited:	56\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Developmental psychopathology / Psychosis / Risk factors

Document

Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.01
Location:	Arquivo PCA - Pasta 18/2006
Title:	Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year:	2010
URL:	http://www.bial.com/imagem/Bolsa3606_16102013.pdf
Abstract/Results:	RESULTS: This study evaluated 54 first psychotic episode patients and 46 healthy controls, using multimodal imaging (structural and functional), to identify the neuroanatomical and functional correlates of neurological performance. Patients showed more neurological signs than controls. There were no significant differences in grey and white matter volumes between patients and controls, although patients had larger, at trend-level, CSF volumes. Global brain volumes were not correlated with performance at any of the neurological subscales. Preliminary analysis of white matter tracts in patients showed that a worse performance in Primary signs, reflecting more “hard” neurological abnormalities, was associated with disruption of tracts integrity, and specifically with: increased Fractional Anisotropy (FA) of the Corpus Callosum, both Uncinate fasciculi, right Inferior Fronto-Occipital fasciculus (IFOF); left Inferior Longitudinal fasciculus (ILF). A worse performance on Motor Sequencing was associated with a shorter length of the right IFOF, and a worse performance in Sensory Integration was correlated with a reduction in right Mean Diffusivity of this fasciculus. An Audio-Visual task was successfully developed to investigate sensory integration during functional MRI. Patients had longer reaction time, and gave more incorrect answers, and had larger frontal lobe activation than healthy controls, particularly so if they had a poorer response to treatment. In conclusion, morpho-anatomical information alone are not sufficient to define the substrate of neurological dysfunction in psychosis, which is likely to reflect an altered structural, and possibly functional connectivity.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Dazzan, P.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Psychosis / Neurological signs / Functional magnetic resonance imaging (fMRI) / Sensory integration
Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imagin

Document

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.02
Location:	Arquivo PCA - Pasta 18/2006
Title:	Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
Publication year:	2010
URL:	http://www.ncbi.nlm.nih.gov/pubmed/20071148
Abstract/Results:	ABSTRACT: This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Mondelli, V.
Secondary author(s):	Pariante, C., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R., Dazzan, P.
Document type:	Article
Number of reproductions:	1
Reference:	Mondelli, V., Pariante, C., Navari, S., Aas, M., D'Albenzio, A., ... Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75-8. https://doi.org/10.1016/j.schres.2009.12.021
2-year Impact Factor:	4.374\|2010
Times cited:	111\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Cortisol / Hippocampus / Psychosis / Hypothalamic-pituitary-adrenal axis / Schizophrenia / Glucocorticoids
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Document

Neurological abnormalities and cognitive ability in first-episode psychosis

2008

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Neurological abnormalities and cognitive ability in first-episode psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.03
Location:	Arquivo PCA - Pasta 18/2006
Title:	Neurological abnormalities and cognitive ability in first-episode psychosis
Publication year:	2008
URL:	http://bjp.rcpsych.org/content/193/3/197.full.pdf+html
Abstract/Results:	ABSTRACT: BACKGROUND: It remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis. AIMS: To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ). METHOD: Evaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general population (n=239). RESULTS: Primary (P<0.001), motor coordination (P<0.001), and motor sequencing (P<0.001) sign scores were significantly higher in people with any psychosis than in the control group. However, only primary and motor coordination scores remained higher when individuals with psychosis and controls were matched for premorbid and current IQ. CONCLUSIONS: Higher rates of primary and motor coordination signs are not associated with lower cognitive ability, and are specific to the presence of psychosis.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., Orr, K., Hutchinson, G., Fearon, P., Allin, M., Rifkin, L., McGuire, P., Doody, G. A., Holloway, J., Leff, J., Harrison, G., Jones, P., Murray, R.
Document type:	Article
Number of reproductions:	1
Reference:	Dazzan, P., Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., ... Murray, R. (2008). Neurological abnormalities and cognitive ability in first-episode psychosis. British Journal of Psychiatry, 193(3), 197-202. https://doi.org/10.1192/bjp.bp.107.045450
2-year Impact Factor:	5.007\|2008
Times cited:	59\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychophysiology / Psychosis / Neurological signs / Cognitive ability
Neurological abnormalities and cognitive ability in first-episode psychosis

Document

Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.05
Location:	Arquivo PCA - Pasta 18/2006
Title:	Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis
Publication year:	2010
URL:	http://www.ncbi.nlm.nih.gov/pubmed/20529412
Abstract/Results:	ABSTRACT: BACKGROUND: Cognitive impairment, particularly in memory and executive function, is a core feature of psychosis. Moreover, psychosis is characterized by a more prominent history of stress exposure, and by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In turn, stress exposure and abnormal levels of the main HPA axis hormone cortisol are associated with cognitive impairments in a variety of clinical and experimental samples; however, this association has never been examined in first-episode psychosis (FEP). METHOD: In this study, 30 FEP patients and 26 controls completed assessment of the HPA axis (cortisol awakening response and cortisol levels during the day), perceived stress, recent life events, history of childhood trauma, and cognitive function. The neuropsychological battery comprised general cognitive function, verbal and non-verbal memory, executive function, perception, visuospatial abilities, processing speed, and general knowledge. RESULTS: Patients performed significantly worse on all cognitive domains compared to controls. In patients only, a more blunted cortisol awakening response (that is, more abnormal) was associated with a more severe deficit in verbal memory and processing speed. In controls only, higher levels of perceived stress and more recent life events were associated with a worse performance in executive function and perception and visuospatial abilities. CONCLUSIONS: These data support a role for the HPA axis, as measured by cortisol awakening response, in modulating cognitive function in patients with psychosis; however, this association does not seem to be related to the increased exposure to psychosocial stressors described in these patients.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Aas, M.
Secondary author(s):	Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A., Di Forti, M., Fisher, H., Handley, R., Hepgul, N., Marques, T. R., Miorelli, A., Taylor, H., Russo, M., Wiffen, B., Papadopoulos, A., Aitchison, K. J., Morgan, C., Murray, R., Pariante, C.
Document type:	Article
Number of reproductions:	1
Reference:	Aas, M., Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A.,Di Forti, M., . . . Pariante, C. (2010). Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychological Medicine, 41(3), 463-476. https://doi.org/10.1017/S0033291710001170
2-year Impact Factor:	5.200\|2010
Times cited:	97\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Cognition / Cortisol / Hypothalamic-pituitary-adrenal axis / Psychosis / Schizophrenia / Stress

Document

Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis

2011

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.07
Location:	Arquivo PCA - Pasta 18/2006
Title:	Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
Publication year:	2011
URL:	http://www.psyneuen-journal.com/article/PIIS030645301100268X/abstract?rss=yes
Abstract/Results:	ABSTRACT: BACKGROUND: Abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported in patients with psychosis, but it is still unclear how these are related to the clinical symptomatology. Inconsistent findings have emerged from previous studies on the association between cortisol levels and clinical symptoms. Methodological and/or clinical factors, such as patients' diagnosis or illness phase, might partially account for these inconsistencies. The aim of this study was to investigate the association between HPA axis activity and clinical symptoms in first-episode psychosis, taking into account diagnosis and illness phase. METHOD: Saliva samples were collected in 55 subjects with first-episode psychosis to assess the Cortisol Awakening Response (CAR) and diurnal cortisol levels (AUC-DAY). Severity of symptoms was assessed with the Positive and Negative Syndrome Scale (PANSS). Scores for subscales and symptom dimensions were used as predictors in multivariate analyses in different diagnostic subgroups and in clinically remitted patients. In addition, a systematic review of the literature on this topic was conducted. RESULTS: In subjects with schizophrenia (n=36), the CAR was predicted by the severity of positive symptoms (beta=0.47, p=0.04); in subjects with depressive psychoses (n=8) the CAR was predicted by excitement (beta=0.58, p=0.005), disorganization (beta=0.39, p=0.007) and depressive symptoms (beta=0.32, p=0.005). In patients with bipolar psychoses (n=11) AUC-DAY was predicted negatively by disorganization (beta=-2.82, p=0.009) and positively by excitement (beta=2.06, p=0.009) and positive symptoms (beta=1.28, p=0.02). In the sample in clinical remission (n=9), the CAR was associated with the severity of positive symptoms (beta=1.34, p=0.009) and, negatively, with excitement (beta=-1.05, p=0.04). The systematic review (on a total of 28 papers, including n=1022 patients), found that in patients with psychosis cortisol levels have been associated with the severity of multiple symptom dimensions. CONCLUSIONS: HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis. Patients' diagnosis and clinical phase partially influence these associations.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Belvederi Murri, M.
Secondary author(s):	Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., Mondelli, V.
Document type:	Article
Number of reproductions:	1
Reference:	Belvederi Murri, M., Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., & Mondelli, V. (2011). Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis. Psychoneuroendocrinology, 37(5), 629-644. https://doi.org/10.1016/j.psyneuen.2011.08.013
2-year Impact Factor:	5.809\|2011
Times cited:	69\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Cortisol / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis / Symptoms / Psychosis / Schizophrenia / Bipolar / Depression / Diagnosis / Remission / Neuroendocrinology

Document

Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

2012

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.08
Location:	Arquivo PCA - Pasta 18/2006
Title:	Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients
Publication year:	2012
URL:	http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656010&fulltextType=RA&fileId=S0033291711002947
Abstract/Results:	ABSTRACT: BACKGROUND: The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls. METHOD: Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors. RESULTS: Patients with childhood maltreatment had higher BMI [25.0 (S.E.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (S.E.=0.6) mg/dl] when compared with healthy controls [23.4 (S.E.=0.4) kg/m2, p=0.030 and 0.2 (S.E.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (S.E.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (S.E.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F 2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue. CONCLUSIONS: Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Hepgul, N.
Secondary author(s):	Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R., Mondelli, V.
Document type:	Article
Number of reproductions:	1
Reference:	Hepgul, N., Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., . . . Mondelli, V. (2012). Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychological Medicine, 42(9), 1893-1901. https://doi.org/10.1017/S0033291711002947
2-year Impact Factor:	5.587\|2012
Times cited:	84\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Body mass index / Childhood maltreatment / Inflammation / Metabolic syndrome / Psychosis

Document

Psychosis, neurological soft signs and their meaning

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Psychosis, neurological soft signs and their meaning

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.11
Location:	Arquivo PCA - Pasta 18/2006
Title:	Psychosis, neurological soft signs and their meaning
Publication year:	2009
URL:	http://library.wfsbp.org/fileadmin/user_upload/wfsbp2009-abstracts.pdf
Abstract/Results:	ABSTRACT: OBJECTIVES: An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure. METHODS: We evaluated 49 individuals (mean age 27 years +-8; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods. RESULTS: Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (p=0.007). Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (p=0.05 and p=0.072 respectively). CONCLUSIONS: Primary and motor coordination deficits may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dazzan, P.
Document type:	Abstract book
Number of reproductions:	1
Reference:	Dazzan, P. (2009). Psychosis, neurological soft signs and their meaning. In Abstracts of the 9th World Congress of Biological Psychiatry (pp. 47-48). Paris, France: World Federation of Societies of Biological Psychiatry. https://doi.org/10.3284/wfsbp.2009.1
Indexed document:	No
Keywords:	Neurological signs / Psychosis / Brain structure / Functional magnetic resonance imaging (fMRI)
Psychosis, neurological soft signs and their meaning

Document

Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

2009

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.12
Location:	Arquivo PCA - Pasta 18/2006
Title:	Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode
Publication year:	2009
URL:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results:	ABSTRACT: Introduction: An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure. Methods: We evaluated 49 individuals (mean age 27 years 68; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods. Results: Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (P = .007). Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (P = .05 and P = .07 respectively). Conclusions: Primary and motor coordination deficits may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., Hutchinson, G., McGuire, P., Jones, P., Leff, J., Fearon, P., Murray, R., Lappin, J.
Document type:	Abstract
Number of reproductions:	1
Reference:	Dazzan, P., Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., . . . Lappin, J. (2009). Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode. Schizophrenia Bulletin, 35(Suppl. 1), 207-207.
Indexed document:	Yes
Keywords:	Neurological signs / Psychosis / Schizophrenia / Functional magnetic resonance imaging (fMRI) / Trait markers
Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

Document

The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

2010

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
      - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-036
Location:	Arquivo PCA - Pasta 18/2006
Title:	036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration:	2007-03 - 2010-09
Researcher(s):	Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s):	Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code:	PT/FB/BL-2006-036.18
Location:	Arquivo PCA - Pasta 18/2006
Title:	The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year:	2010
URL:	http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results:	ABSTRACT: OBJECTIVES: This project investigated the anatomical and functional correlates of one of the few objective clinical correlate of psychosis, neurological abnormalities. These are abnormalities of sensory and motor function found in excess in patients with psychosis, and, to a lesser extent, in the general population. These neurological abnormalities may represent a specific clinical sign of the perturbed cortical-subcortical connectivity that putatively underlies psychotic disorders. METHODS: In a sample of patients at the first-episode of psychosis and in healthy controls we evaluated neurological function in four functional areas: 1) “Primary neurological dysfunction” (dysfunction that can be identified by a standard neurological examination); 2) “Sensory integration dysfunction” (dysfunction in the integration of sensory information); 3) “Motor coordination dysfunction” (motor incoordination); 4) “Motor sequencing dysfunction” (performance of complex motor sequences). We also used: structural Magnetic Resonance Imaging (sMRI) to estimate volumes of grey and white matter, and cerebro-spinal fluid (CSF); Diffusion Tensor Imaging (DTI) and DTI Tractography to estimate white matter integrity of Corpus Callosum, Uncinate Fasciculus, Inferior Fronto-occipital Fasciculus, Inferior Longitudinal Fasciculus; functional Magnetic Resonance Imaging (fMRI) for brain activation during an Audio-visual integration task and a Motor movement task. RESULTS: A total of 54 patients and 46 healthy individuals were recruited in the study. Patients showed significantly higher scores than healthy individuals in all areas of neurological performance (p<0.05), with the exception of motor coordination. Global volumes of grey and white matter, and CSF were not correlated with performance on any neurological subscale. In contrast, a worse performance in Primary signs was consistently associated with disruption of white matter integrity of the Corpus Callosum (p=0.05), Uncinate fasciculus (p=0.059), Inferior Fronto-Occipital fasciculus (p=0.049), and Inferior Longitudinal fasciculus (p=0.01). CONCLUSIONS: Neurological signs in psychoses are likely to reflect the alteration in connectivity that has been suggested to be one of the key pathophysiological processes occurring in these disorders. In the next step, the analysis will focus on the functional data, to evaluate whether the areas connected by these tracts are also impaired in function.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dazzan, P.
Secondary author(s):	McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Dazzan, P., McGuire, P., Pariante, C., Di Forti, M., Lappin, J., & Mondelli, V. (2010). The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 204). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Neurological signs / Schizophrenia / Psychosis / Functional magnetic resonance imaging (fMRI) / Diffusion tensor imaging (DTI)
The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

Document

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

2013

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.18
Location:	Arquivo PCA - Pasta 17/2006
Title:	Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
Publication year:	2013
URL:	http://www.schres-journal.com/article/S0920-9964(12)00701-3/abstract
Abstract/Results:	ABSTRACT: BACKGROUND: Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9–11years at study commencement. METHODS: 8099 children (mean age 10.4years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later. RESULTS: Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13–3.34) and externalising (OR=1.97; 95% CI 1.19–3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs. CONCLUSIONS: Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Downs, J. M.
Secondary author(s):	Cullen, A. E., Barragan, M., Laurens, K. R.
Document type:	Article
Number of reproductions:	1
Reference:	Downs, J. M., Cullen, A. E., Barragan, M., & Laurens, K. R. (2013). Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Schizophrenia Research, 144(1), 99-104. https://doi.org/10.1016/j.schres.2012.12.009
2-year Impact Factor:	4.426\|2013
Times cited:	68\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Childhood / Adolescence / Developmental psychopathology / Community sample / Risk factors / Psychosis
Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Document

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years

2013

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.19
Location:	Arquivo PCA - Pasta 17/2006
Title:	Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years
Publication year:	2013
URL:	http://www.sciencedirect.com/science/article/pii/S0022395613000964
Abstract/Results:	ABSTRACT: Social withdrawal is a robust childhood risk factor for later schizophrenia. The aims of this paper were to assess the evidence for childhood social withdrawal among adults with schizophrenia and, comparatively, in children aged 9–14 years who are putatively at-risk of developing schizophrenia. We conducted a meta-analysis, including cohort and case-control studies reporting social withdrawal measured by the Child Behavior Checklist (CBCL) in adults with schizophrenia vs. controls. Further, an experimental study compared CBCL withdrawal scores from typically-developing children with scores from two groups of putatively at-risk children: (i) children displaying a triad of replicated antecedents for schizophrenia, and (ii) children with at least one first- or second-degree relative with schizophrenia or schizoaffective disorder. Six studies met inclusion criteria for the meta-analysis (N = 3828), which demonstrated a large effect of increased childhood social withdrawal in adults with schizophrenia (standardized mean difference [SMD] score = 1.035, 95% CI = 0.304–1.766, p = 0.006), with no indication of publication bias, but considerable heterogeneity (I2 = 91%). Results from the experimental study also indicated a large effect of increased social withdrawal in children displaying the antecedent triad (SMD = 0.743, p = 0.001), and a weaker effect in children with a family history of schizophrenia (SMD = 0.442, p = 0.051). Childhood social withdrawal may constitute a vulnerability marker for schizophrenia in the presence of other antecedents and/or genetic risk factors for schizophrenia.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Matheson, S. L.
Secondary author(s):	Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., Laurens, K. R.
Document type:	Article
Number of reproductions:	1
Reference:	Matheson, S. L., Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., & Laurens, K. R. (2013). Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years. Journal of Psychiatric Research, 47(8), 1061-1068. https://doi.org/10.1016/j.jpsychires.2013.03.013
2-year Impact Factor:	4.092\|2013
Times cited:	48\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Child Behavior Checklist (CBCL) / Antecedents / Risk factors / Psychosis / Developmental psychopathology
Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years

Document

Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia

2013

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.20
Location:	Arquivo PCA - Pasta 17/2006
Title:	Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia
Publication year:	2013
URL:	http://schizophreniabulletin.oxfordjournals.org/content/39/6/1318
Abstract/Results:	ABSTRACT: Distributed abnormalities of gray matter (GM) and white matter (WM) volume characterize individuals experiencing their first episode of schizophrenia. Regions of abnormality are present already, albeit less extensively, during the prodromal phase of illness. This study aimed to determine whether putatively at-risk children, aged 9–12 years, who present multiple antecedents of schizophrenia (ASz), display GM and WM volume abnormalities relative to typically developing (TD) children presenting no antecedents. Structural magnetic resonance images were acquired for 20 ASz children and 20 TD children matched on age, sex, and IQ. Whole-brain differences in GM and WM volume were determined using voxel-based morphometry. Relative to the TD group, ASz children showed significantly decreased GM volume in the right middle temporal gyrus (MTG) and increased GM volume in the left superior-middle temporal gyri (P < 0.05, cluster correction). WM volume was significantly increased in ASz children relative to TD children in a cluster encompassing the left inferior parietal lobe, occipital lobe, and superior temporal gyrus. Post-hoc analyses indicated that these abnormalities were not limited to ASz children who self-reported auditory hallucinations on questionnaire. Our findings suggest that children aged 9–12 years who present multiple ASz are characterized by abnormalities of GM and WM volume in the temporal lobes, comprising a subset of the regions affected in first-episode schizophrenia and in the prodromal phase of illness. These preliminary findings indicate that structural brain abnormalities associated with schizophrenia may be detected in putatively at-risk, preprodromal children. Prospective studies following the brain development of at-risk children are needed.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Cullen, A. E.
Secondary author(s):	de Brito, S. A., Gregory, S., Murray, R., Williams, S., Hodgins, S., Laurens, K. R.
Document type:	Article
Number of reproductions:	1
Reference:	Cullen, A. E., de Brito, S. A., Gregory, S., Murray, R., Williams, S., Hodgins, S., & Laurens, K. R. (2013). Temporal lobe volume abnormalities precede the prodrome: A study of children presenting antecedents of schizophrenia. Schizophrenia Bulletin, 39(6), 1318-1327. https://doi.org/10.1093/schbul/sbs128
2-year Impact Factor:	8.607\|2013
Times cited:	39\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychosis / High-risk / Magnetic resonance imaging (MRI) / Voxel based morphometry (VBM) / Biomarkers / Brain structure
Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia

Document

Cognitive impairment among children at-risk for schizophrenia

2014

BIAL Foundation Archive
- BIAL Grants
  - 2006 Grants
    - 035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
      - Cognitive impairment among children at-risk for schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2006
Location:	Arquivo PCA - Pastas 1 a 22 /2006
Title:	2006 Grants
Start date:	2007-01 - 2013-11
Dimension/support:	22 caixas de arquivo

Reference code:	PT/FB/BL-2006-035
Location:	Arquivo PCA - Pasta 17/2006
Title:	035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration:	2008-01 - 2011-07
Researcher(s):	Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s):	Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report 5 Articles (under review or published) 1 Book chapter
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2006-035.23
Location:	Arquivo PCA - Pasta 17/2006
Title:	Cognitive impairment among children at-risk for schizophrenia
Publication year:	2014
URL:	http://www.sciencedirect.com/science/article/pii/S0022395613003695
Abstract/Results:	ABSTRACT: Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definition of risk and/or on the degree of relatedness to an affected individual, and if impairments were explained by IQ. Four groups of children aged 9–12 years were studied: (1) 13 children with =1 first-degree or =2 second-degree affected relatives (high familial loading: FHxH); (2) 14 with =1 affected second-degree relative (lower familial loading: FHxL); (3) 32 with well-replicated antecedents of schizophrenia (ASz); and (4) 45 typically-developing (TD) children with neither a positive family history nor antecedents. Compared to TD children, both FHxH and ASz children exhibited significantly poorer verbal comprehension, scholastic achievement, and verbal working memory, while FHxH children additionally displayed significantly lower full-scale IQ, and verbal memory and executive function impairments. After adjusting statistical analyses for IQ, group differences were attenuated. Relative to TD children, FHxL children showed no significant differences in performance. The results imply that impairments in verbal comprehension, scholastic achievement, and verbal working memory may index vulnerability for schizophrenia among children with affected relatives with the disorder and among those with multiple antecedents of the disorder who have no affected relatives. More accurate identification of children at-risk for schizophrenia and the specific deficits that they present provides opportunities for interventions such as cognitive remediation that may impact the development of the illness.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dickson, H.
Secondary author(s):	Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D., Morris, R., Laurens, K. R.
Document type:	Article
Number of reproductions:	1
Reference:	Dickson, H., Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D., Morris, R. G., & Laurens, K. R. (2014). Cognitive impairment among children at-risk for schizophrenia. Journal of Psychiatric Research, 50, 92-99. https://doi.org/10.1016/j.jpsychires.2013.12.003
2-year Impact Factor:	3.957\|2014
Times cited:	34\|2025-02-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Intelligence / Psychosis / Risk factors / Genetic liability / Developmental psychopathology / Psychotic-like experiences

Document

Genetic and environmental bases of the interplay between magical ideation and personality

2014

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 262 - The neural basis of Magical Ideation: A multimodal imaging study in twin subjects
      - Genetic and environmental bases of the interplay between magical ideation and personality

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-262
Location:	Arquivo PCA - Pasta 29/2012
Title:	262 - The neural basis of Magical Ideation: A multimodal imaging study in twin subjects
Duration:	2013-08 - 2019-07
Researcher(s):	Paolo Brambilla, Gioia Negri, Sara Piccin, Giuseppe Cabras, Corrado Fagnani
Institution(s):	Universitá delgi Studi di Milano and Unit of Epidemiology of the Italian Institute of Health, Rome (Italy)
Contents:	Contents: Bursary agreement Application form Correspondence Progress report Final report Articles
Language:	eng
Author:	Brambilla, P.
Secondary author(s):	Negri, G., Piccin, S., Cabras, G., Fagnani, C.
Number of reproductions:	3
Keywords:	Psychophysiology and Parapsychology / Paranormal belief / Brain structure and function / Personality

Reference code:	PT/FB/BL-2012-262.03
Location:	Arquivo PCA - Pasta 29/2012
Title:	Genetic and environmental bases of the interplay between magical ideation and personality
Publication year:	2014
URL:	http://www.psy-journal.com/article/S0165-1781(13)00753-1/abstract
Abstract/Results:	ABSTRACT: Sub-threshold psychotic symptoms are quite commonly present in general population. Among these, Magical Ideation (MI) has been proved to be a valid predictor of psychosis. However, the genetic and environmental influences on the interplay between MI and personality have not fully been explored. A total of 534 adult twins from the population-based Italian Twin Register were assessed for MI using the MI Scale (MIS) and for personality with the temperament and character inventory (TCI). A Multivariate Cholesky model was applied with Mx statistical program. The best-fitting model showed that additive genetic and unshared environmental factors explain approximately the same proportion of variance in MI, whereas a less strong genetic influence on personality traits emerged. Relevant correlations between MI and specific personality traits (novelty seeking, cooperativeness, self-directedness, self-transcendence) were found, suggesting shared influences for MI and these traits. Both genetic and environmental factors explained these correlations, with genetic factors playing a predominant role. Moderate-to-substantial genetic effects on MI and personality were found. Shared genetic and environmental effects underlie the phenotypic correlation between MI (psychosis-proneness) and personality traits, i.e. self-directedness (negative association) and self-transcendence (positive association), potentially representing predictive markers of psychosis liability related to schizotypy and personality.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Brambilla, P.
Secondary author(s):	Fagnani, C., Cecchetto, F., Medda, E., Bellani, M., Salemi, M., Picardi, A., Stazi, M. A.
Document type:	Article
Number of reproductions:	3
Reference:	Brambilla, P., Fagnani, C., Cecchetto, F., Medda, E., Bellani, M., Salemi, M., Picardi, A., & Stazi, M. A. (2014). Genetic and environmental bases of the interplay between magical ideation and personality. Psychiatry Research, 215(2), 453-459. https://doi.org/10.1016/j.psychres.2013.11.021
2-year Impact Factor:	2.467\|2014
Times cited:	15\|2025-02-10
Indexed document:	Yes
Quartile:	Q2
Keywords:	Magical ideation / Twins / Temperament and character inventory / Schizotypy / Psychosis / Self-directedness / Self-transcendence
Genetic and environmental bases of the interplay between magical ideation and personality

Document

Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study

2016

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 194 - Characterising developmental trajectories of brain function from childhood into adolescence
      - Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-194
Location:	Arquivo PCA - Pasta 25/2012
Title:	194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration:	2013-04 - 2017-09
Researcher(s):	Kristin Robin Laurens, Ruth E. Roberts
Institution(s):	Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Bursary agreement Application form Correspondence Progress reports Final report
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Roberts, R.
Number of reproductions:	1
Keywords:	Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code:	PT/FB/BL-2012-194.03
Location:	Arquivo PCA - Pasta 25/2012
Title:	Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study
Publication year:	2016
URL:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823320/
Abstract/Results:	ABSTRACT: PURPOSE: The London Child Health and Development Study (CHADS) is a prospective, longitudinal investigation of children, sampled from the general community aged 9-11 years and assessed biennially, who present premorbid risk markers for schizophrenia. The study aims to characterise developmental trajectories of psychological, cognitive, and biological functioning in at-risk children and identify potential targets for early preventative intervention. This review summarises CHADS findings, discusses these in the context of recent theory regarding aetiology and prevention of schizophrenia, and highlights challenges to be addressed with future research. METHODS: We review (1) epidemiological information on the prevalence and correlates of developmental antecedents of schizophrenia in the general child population, (2) evidence of psychosocial, cognitive, and biological dysfunctions in at-risk children presenting multiple antecedents of schizophrenia and at-risk children with a family history of schizophrenia, and (3) related findings from an associated sample of help-seeking children receiving intervention. RESULTS: Community-based screening of 9-11-year olds identified ~9 % with a triad of antecedents of schizophrenia [including psychotic-like experiences (PLEs)] who are putatively at-risk of psychosis; these children reported greater exposure and responsivity to stressors, impairments in general intelligence and specific cognitive functions, brain structure and function abnormalities, and neuromotor dysfunction. Preliminary evidence suggests distressing PLEs are a viable target for cognitive-behavioural intervention in at-risk children. CONCLUSIONS: Intervention in early, premorbid phases of illness might alleviate current difficulties and avert future schizophrenia using benign treatments. The CHADS programme has identified several markers that may index early pathophysiology and constitute potential targets for preventative intervention.
Accessibility:	Document exists in file
Language:	eng
Author:	Laurens, K. R.
Secondary author(s):	Cullen, A. E.
Document type:	Article
Number of reproductions:	1
Reference:	Laurens, K. R., & Cullen, A. E. (2016). Toward earlier identification and preventative intervention in schizophrenia: Evidence from the London Child Health and Development Study. Social Psychiatry and Psychiatric Epidemiology, 51(4), 475-491. https://doi.org/10.1007/s00127-015-1151-x
2-year Impact Factor:	2.922\|2016
Times cited:	53\|2025-02-11
Indexed document:	Yes
Quartile:	Q2
Keywords:	Adolescence / Developmental psychopathology / High-risk / Psychosis / Psychotic-like experiences
Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study