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067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

2000-12

2003-12

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Document

Final report - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

2004

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Final report - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.01
Location:	Arquivo PCA - Pasta 10/2000
Title:	Final report - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year:	2004
URL:	http://www.bial.com/imagem/Bolsa6700_19022014.pdf
Abstract/Results:	RESULTS: The project was designed to evaluate the possibility of using gene therapy at the central nervous system as an analgesic tool. Pain suppression through central electrical stimulation, although effective as an analgesic tool, is impracticable since serious secondary effects occur due to stimulation of neurons involved in other brain functions. Viral vector transduction stands nowadays as a way of overcoming this problem by directing manipulation specifically to pain-control neurons. We focused on the possibility of concomitantly inhibit a pain facilitatory center (DRt) and stimulate a pain inhibitory center (VLM) by the use of multiple transduction from each site with the replication-defective herpes simplex virus (HSV-1). The migration pattern following injection of HSV-1 in the DRt and VLM was studied. In parallel, information on the membrane receptors present in the neurons to be targeted (DRt and VLM pain processing neurons) and on the neurotransmitters used by the neurons to be transduced was collected. The results collected allowed us to conclude that HSV-1 is particularly well suited for the purpose of the project since it transduces just a few brain areas projecting to the VLM and DRt, allowing a limited but still amplified action upon each one, and areas other than the DRt and VLM that receive axonal terminations of transduced neurons are few. The neurochemical data point to the use of vectors coding for the GABAB receptor, GAD and noradrenalin at the DRt, and of vectors coding for GABAB and a2 receptor antisense molecules at the VLM. Behavior and pharmacological studies aimed at elucidating the effect of appropriate drugs upon injection in the sites of termination of the transduced neurons are however still needed.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Lima, D.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Pain
Relatório final - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Document

The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat

2003

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.02
Location:	Arquivo PCA - Pasta 10/2000
Title:	The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat
Publication year:	2003
URL:	http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02782.x/abstract
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=213&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: Single-unit spinal recordings combined with application of glutamate into the medullary dorsal reticular nucleus were used to assess the action of this nucleus upon deep dorsal horn neurons in rats. Injection of high glutamate concentrations (10 and 100 mm) induced a dramatic and long-lasting increase of the responses of wide-dynamic range neurons to electrical stimulation of the sciatic nerve in the noxious range, without affecting ongoing discharges. Post-stimulus time histograms revealed that this increase concerned the post-discharge, but not A- or C-fibre-mediated responses, which remained unchanged independently of the stimulation frequency applied. The onset of the glutamate-induced response enhancement occurred with a concentration-dependent time delay and developed slowly until its maximum. These data indicate that the medullary dorsal reticular nucleus exerts a facilitating action upon deep dorsal horn wide-dynamic range neurons by enhancing their capacity to respond to peripheral stimulation through prolongation of their discharge. This action is accompanied by the strengthening of wind-up of deep dorsal horn wide-dynamic range neurons, hence providing a plausible substrate for chronic pain states. These results are in agreement with previous behavioural studies suggesting a pronociceptive role for the dorsal reticular nucleus [Almeida et al. (1996) Brain Res. Bull., 39, 7-15; Almeida et al. (1999) Eur. J. Neurosci., 11, 110-122], and support the involvement of a reverberating circuit, previously described in morphological studies [Almeida et al. (1993) Neuroscience, 55, 1093-1106; Almeida et al. (2000) Eur. J. Pain, 4, 373-387], which probably operates only at a certain threshold of activation.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dugast, C.
Secondary author(s):	Almeida, A., Lima, D.
Document type:	Article
Number of reproductions:	1
Reference:	Dugast, C., Almeida, A., & Lima, D. (2003). The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat. European Journal of Neuroscience, 18(3), 580-588. https://doi.org/10.1046/j.1460-9568.2003.02782.x
2-year Impact Factor:	3.872\|2003
Times cited:	33\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Electrophysiology / Facilitation / Pain / Wide-dynamic range / Wind-up

Document

Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors

2003

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.03
Location:	Arquivo PCA - Pasta 10/2000
Title:	Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors
Publication year:	2003
URL:	http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02586.x/abstract
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=215&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: Modulation of nociceptive transmission at the brainstem involves several neurochemical systems. The precise location and specific characteristics of nociceptive neurons activated in each system was never reported. In this study, the presence of GABA(B), mu-opioid, and neurokinin-1 (NK-1) receptors in brainstem nociceptive neurons was investigated by double-immunocytochemical detection of each receptor and noxious-evoked induction of the c-fos proto-oncogene. Noxious cutaneous mechanical stimulation significantly increased the proportions of neurons double-labelled for Fos and GABA(B) receptors in several brainstem regions, namely, the reticular formation of the caudal ventrolateral medulla (VLMlat and VLMrf), lateral reticular nucleus, spinal trigeminal nucleus, pars caudalis (Sp5C), nucleus of the solitary tract, dorsal reticular nucleus, ventral reticular nucleus, raphe obscurus nucleus and dorsal parabrachial nucleus (DPB). For mu-opioid receptors, the proportions of double-labelled neurons in noxious-stimulated animals were higher than in controls only in the VLMlat, VLMrf, Sp5C, DPB and A5 noradrenergic cell group. As for the NK-1 receptor, no significant differences were found between control and stimulated animals. According to these results, neurons expressing GABA(B), mu-opioid and NK-1 receptors at several pain control centres of the brainstem are differentially involved in processing nociceptive mechanical input. The data provide the definition of new supraspinal targets for selective modulation of nociceptive neurons in order to define better strategies of pain control.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Related objects:	PT/FB/BL-2000-67.08
Author:	Pinto, M.
Secondary author(s):	Lima, D., Castro-Lopes, J. M., Tavares, I.
Document type:	Article
Number of reproductions:	1
Reference:	Pinto, M., Lima, D., Castro-Lopes, J., & Tavares, I. (2003). Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABA(B), mu-opioid and NK-1 receptors. European Journal of Neuroscience, 17(7), 1393-1402. https://doi.org/10.1046/j.1460-9568.2003.02586.x
2-year Impact Factor:	3.872\|2003
Times cited:	36\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Antinociception / Double immunocytochemistry / Pain / Rat
Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors

Document

Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

2002

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.04
Location:	Arquivo PCA - Pasta 10/2000
Title:	Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation
Publication year:	2002
URL:	http://jn.physiology.org/content/88/4/2096.full.pdf
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=217&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: Reorganization of central networks and plasticity of neuronal representations have been implicated in recent years in the dynamic expression of somatosensory responses. The functional properties of spinal cells were shown to change in the scale of minutes after peripheral high-intensity stimulations and to undergo profound alterations in their responses in experimental models of chronic pain. These observations, however, are restricted to recordings from individual cells, and no information exists on how these changes may be reflected on the activity of somatosensory neuronal networks involved in pain processing. To understand how spinal cord networks may be altered after the onset of hyperalgesia, we extracellularly recorded from groups of five to nine neighboring neurons in the hindlimb representation area of the dorsal horn. The multineuronal activity evoked by cutaneous innocuous and noxious stimulation was compared before and for 3 h after the subcutaneous injection of diluted formalin. Formalin caused immediate changes in response properties and mechanical threshold of activation for the majority of the neurons and induced the incorporation of previously unresponsive neighboring neurons to the functional network. Analysis of the temporal correlation within the neuronal population revealed that formalin-induced inflammation increased the functional coherence of the network to the nonnociceptive stimulation but not to the painful stimuli. This increase in the tactile acuity of populations of nociceptive neurons may be a basis for the emergence of touch-evoked pain.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Galhardo, V.
Secondary author(s):	Apkarian, A. V., Lima, D.
Document type:	Article
Number of reproductions:	1
Reference:	Galhardo, V., Apkarian, A. V., & Lima, D. (2002). Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation. Journal of Neurophysiology, 88(4), 2096-2103. https://doi.org/10.1152/jn.00720.2001
2-year Impact Factor:	3.743\|2002
Times cited:	6\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychophysiology / Pain
Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

Document

Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat

2001

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.06
Location:	Arquivo PCA - Pasta 10/2000
Title:	Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat
Publication year:	2001
Accessibility:	Document does not exist in file
Language:	eng
Author:	Dugast, C.
Secondary author(s):	Almeida, A., Lima, D.
Document type:	Abstract
Number of reproductions:	1
Reference:	Dugast, C., Almeida, A., & Lima, D. (2001). Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat. Journal of Pain, 2(Suppl.1), 23.
Indexed document:	Yes
Keywords:	Psychophysiology / Pain

Document

Spino-medullary circuitry in nociceptive cardiovascular integration

2001

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Spino-medullary circuitry in nociceptive cardiovascular integration

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.07
Location:	Arquivo PCA - Pasta 10/2000
Title:	Spino-medullary circuitry in nociceptive cardiovascular integration
Publication year:	2001
URL:	http://www.physoc.org/proceedings/abstract/J%20Physiol%20536PS290
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=222&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: Nociceptive spinofugal pathways terminating at the caudal medulla oblongata target the dorsoreticular nucleus (DRt), the nucleus tractus solitarii (NTS) and the caudal ventrolateral reticular formation (VLM). While the spino-DRt pathway is involved in triggering pain-facilitating effects from the DRt, the spino-NTS and spino-VLM pathways have been implicated in nociceptive-cardiovascular integration. Spinal dorsal horn neurones involved are distributed through laminae I and IV-V. Curiously, the medullary projections of the two neuronal populations are in all cases segregated, pointing to differences in the role played by each of them. In the DRt, lamina I targets the ipsilateral dorsal-most portion, immediately beneath the cuneate nucleus, and laminae IV-V the remaining ventral two-thirds, bilaterally. In the NTS, lamina I targets the medial commissural subnucleus, bilaterally, and laminae IV-V the lateral subnucleus, ipsilaterally. In the VLM, lamina I targets the reticular formation (VLMlat) located between the lateral reticular nucleus (LRt) and the spinal trigeminal nucleus, pars caudalis, and laminae IV-V the lateral portion of the LRt. Furthermore, the structural types of lamina I neurones participating in the spino-NTS and spino-VLM pathways are the same (fusiform, pyramidal and flattened), while those projecting to the DRt differ, belonging mainly in the multipolar type followed by the pyramidal and flattened types. Both the NTS and VLM exert anti-nociceptive effects as revealed by the depression of nociceptive reflexes and inhibition of nociceptive responses of spinal neurones upon local stimulation. Direct pathways connect the NTS commissural subnucleus and the VLMlat with both superficial and deep spinal dorsal horn laminae. The VLMlat is also connected with the spinal cord through a disynaptic pathway relaying in the pontine A5 noradrenergic group, which is thought to convey the spinal a2-adrenoreceptor-mediated anti-nociception elicited from the VLM. The well-known role of the NTS commissural subnucleus and the VLM in cardiovascular control, together with the demonstration that they are sites of termination of nociceptive spinal afferents, has been taken as a strong indication of the involvement of both areas in nociceptive and cardiovascular integration, namely in the genesis of autonomic reactions to pain. Taking into account their role in pain control, it is also possible that both areas can modulate spinal nociceptive transmission in response to changes in cardiovascular parameters. Hypertensive subjects, either humans or experimental animals, were shown to have higher pain thresholds than normotensive subjects. In spite of the large amount of data supporting those hypotheses, experimental studies aimed at their evaluation are lacking. We have recently addressed this issue by investigating the role of the VLM in hypertension-induced hypoalgesia. In rats in which hypertension was produced by either pharmacological (L-NAME) or surgical (renal artery constriction) means, spinal c-fos induction following noxious mechanical stimulation of the skin was reduced compared with normotensive animals. Lesioning the VLM in hypertensive animals prior to noxious stimulation prevented the decrease in spinal c-fos expression. Since the hypertension-induced hypoalgesia is mediated by spinal a2-adrenoreceptors, and the noradrenergic anti-nociceptive effects of the VLM are conveyed by the VLMlat-A5-spinal circuit, the observed VLM-dependent decrease of spinal c-fos expression in response to rises in blood presure is most likely accounted for by the VLMlat. On the other hand, the VLMlat by itself is capable of exerting the vasodepressor effects normally attributed to the VLM, as revealed by decrease in blood pressure and heart rate upon local stimulation and the opposite effect after lesioning. The VLMlat thus seems to be not only the VLM site in charge of pain control through both direct or indirect spinopetal pathways, but also an important centre for nociceptive and cardiovascular integration.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I.
Document type:	Abstract
Number of reproductions:	1
Reference:	Lima, D., & Tavares, I. (2001). Spino-medullary circuitry in nociceptive cardiovascular integration. Journal of Physiology-London, 536(Suppl.), 18S-19S.
Indexed document:	Yes
Keywords:	Psychophysiology / Pain

Document

Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat

2003

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.09
Location:	Arquivo PCA - Pasta 10/2000
Title:	Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat
Publication year:	2003
URL:	http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results:	ABSTRACT: Previous studies have shown that chronic pain induces changes in the spinal cord, namely in what concerns the neurochemistry of dorsal horn circuits. It has not been yet addressed whether similar changes occur supraspinally namely at the endogenous pain modulatory system. In this study, we investigated the brainstem regions expressing the protooncogene c-fos as a result of mobilization of a chronically inflamed joint and further studied the expression of NK1 receptors in those neurons of those regions. Male Wistar rats were injected in the tiobiotarsal joint with 50 µl of saline (control) or Complete´s Freund Adjuvant (monoarthritic). After 14 days of daily training the animals were subjected to 4 minutes of repeated extensions of the inflamed hindlimb and brainstem frozen sections were double-immunoreacted for Fos protein and NK1 receptors. Monoarthritic rats presented an increase of Fos-immunoreactive neurons in the caudal ventrolateral medulla, lateral, dorsal and ventral reticular nuclei, spinal trigeminal nucleus, nucleus of the solitary tract, raphe obscurus, gracile, cuneate, ambiguous, vestibular and tegmental nuclei. No differences were found in the number of Fos neurons expressing NK1 receptors. Mobilization of a chronically inflamed paw induces functional activation of several areas of the endogenous pain control system, reinforcing the importance of the system in chronic pain. In a manner similar to what occurs in acute pain (Pinto et al., 2003), NK1 receptors do not appear to be involved in supraspinal processing of chronic pain. Pinto M et al., 2003 Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK-1 receptors. Europ. J. Neurosci., 17: 1393-1402.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Tavares, I.
Secondary author(s):	Pinto, M., Lima, D.
Document type:	Online abstract
Number of reproductions:	1
Reference:	Tavares, I., Pinto, M., & Lima, D. (2003). Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat. Program No. 66.13. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience. Online.
Indexed document:	No
Keywords:	Pain / Monoarthritis / NK1 receptors

Document

Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato

2001

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.11
Location:	Arquivo PCA - Pasta 10/2000
Title:	Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato
Publication year:	2001
Accessibility:	Document does not exist in file
Language:	por
Author:	Pinto, M.
Document type:	Master's thesis
Number of reproductions:	1
Reference:	Pinto, M. (2001). Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato (Unpublished master´s thesis). Portugal: Faculdade de Medicina da Universidade de Lisboa.
Indexed document:	No
Keywords:	Psychophysiology / Pain

Document

Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler

2003

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.12
Location:	Arquivo PCA - Pasta 10/2000
Title:	Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler
Publication year:	2003
Accessibility:	Document does not exist in file
Language:	fre
Author:	Martins, I.
Document type:	Master's thesis
Number of reproductions:	1
Reference:	Martins, I. (2003). Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler (Unpublished master´s thesis). Conservatoire National des Arts et Métiers, Paris.
Indexed document:	No
Keywords:	Psychophysiology / Pain / Therapy

File

028 - Emotional factors in placebo analgesia: Psychophysiological Experiments

2003-03

2006-10

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 028 - Emotional factors in placebo analgesia: Psychophysiological Experiments

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-028
Location:	Arquivo PCA - Pasta 10/2002
Title:	028 - Emotional factors in placebo analgesia: Psychophysiological Experiments
Duration:	2003-03 - 2006-10
Researcher(s):	Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Jan Brox, Arnstein Finset
Institution(s):	Department of Clinical Research, University Hospital of North Norway (Norway)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Articles
Language:	eng
Author:	Flaten, M.
Secondary author(s):	Johansen, O., Simonsen, T., Brox, J., Finset, A.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Emotion

Document

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

2002

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.13
Location:	Arquivo PCA - Pasta 10/2000
Title:	Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year:	2002
URL:	http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/4%C2%BA_simposio.a110.html
Accessibility:	Document does not exist in file
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Cobos, A., Pinto, M.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Lima, D., Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Cobos, A., & Pinto, M. (2002). Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 4th Symposium of Fundação Bial (p. 451). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Psychophysiology / Pain
Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Document

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

2004

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
      - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-067
Location:	Arquivo PCA - Pasta 10/2000
Title:	067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration:	2000-12 - 2003-12
Researcher(s):	Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s):	Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report 1 Article
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain

Reference code:	PT/FB/BL-2000-067.14
Location:	Arquivo PCA - Pasta 10/2000
Title:	Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year:	2004
URL:	http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/5%C2%BA_simposio.a111.html
Abstract/Results:	ABSTRACT: The pain system is endowed with control mechanisms that modulate the ascending transmission of nociceptive input by either depressing or enhancing the responsiveness of nociceptive spinal neurons. Although effective, manipulation of brain pain-control centers as an analgesic procedure has no clinical value since it simultaneously affects neurons involved in brain functions other than pain control. In this project we explore the possibility of using viral vectors as a way of targeting specifically pain control neurons through transfection of neuronal cells that establish synaptic contacts with them. The targets chosen were the VLM and DRt because of their potent inhibitory and facilitatory effects, respectively. The studies performed so far aimed at defining a transfection strategy that results in stimulation of the VLM and inhibition of the DRt. A replication-defective Herpes Simplex Virus was chosen since, by being retrogradely transported, it allows transfection of several brain regions projecting to the VLM and DRt, hence amplifying the effect upon each target. The migration dynamics of the virus was studied in order to identify both the brain regions that are putative sources of synaptically mediated pharmacological actions upon each target (soma exhibiting the virus product) and the regions that also receive input from the transfected neurons (axonal arborizations exhibiting the virus product). These data help in selecting the regions to be transfected from the VLM and the DRt as those that project mainly or solely to one of the two areas and do not project significantly to other brain regions. The results point to the A 5 and RVL as areas to be transfected from the VLM, and to the cerebelum, NTS, Ve and Cu as areas to be transfected from the DRt. Complementary studies of the neurochemical nature of the transfected neurons are now in progress as a way of defining the viral construction that better conciliates the desired action upon the neurons in one target without affecting either the other target or neurons that are not involved in pain control. It was already verified that the LC contains noradrenergic neurons transfected from the VLM and DRt, and the A1 and A5 groups contain noradrenergic neurons transfected from the DRt. The surface receptor properties of VLM and DRt nociceptive neurons were evaluated in order to identify the neurotransmitters whose synthesis should be amplified or blocked by the vectors acting upon each target. GABA B receptors were found to occur in nociceptive neurons of both the VLM and DRt, and opioid receptors only in the VLM. These data point to the use of a pré-pro-enkephalin and GABAB antisense construction at the VLM and a GABA precursor construction at the DRt.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Lima, D.
Secondary author(s):	Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Lima, D., Tavares, I., Almeida, A., Dugast, C., Galhardo, V., & Pinto, M. (2004). Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 5th Symposium of Fundação Bial (pp. 309-310). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Psychophysiology / Pain / Viral vectors
Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

File

033 - Dynamic brain patterns in neocortical areas during interpersonal transactions

2005-01

2008-07

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 033 - Dynamic brain patterns in neocortical areas during interpersonal transactions

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-033
Location:	Arquivo PCA - Pasta 15/2004
Title:	033 - Dynamic brain patterns in neocortical areas during interpersonal transactions
Duration:	2005-01 - 2008-07
Researcher(s):	Richard Wennberg, Jose Luis Perez Velazquez
Institution(s):	Krembil Neuroscience Centre, Toronto Western Hospital and The Hospital for Sick Children, University of Toronto (Canada)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng
Author:	Wennberg, R.
Secondary author(s):	Perez Velazquez, J. L.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Pain / Emotion / Empathy

File

084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

2005-01

2008-11

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Document

Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

2008

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.01
Location:	Arquivo PCA - Pasta 19/2004
Title:	Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Publication year:	2008
URL:	http://www.bial.com/imagem/Bolsa8404_21022014.pdf
Abstract/Results:	ABSTRACT: The studies performed in grant 84/04 "THE CONSCIOUSNESS OF PAIN" led to significant advances in our understanding of the neurobiological mechanisms that induce cognitive alterations under chronic pain conditions. Our studies have introduced for the first time the use of complex cognitive tasks in animal models of chronic pain. The relevance of our studies is notorious not only from the quality of the scientific publications in which we have reported our results, but also from the impact that these studies have achieved in the Pain Research scientific community as inferred by the many invitations to present our results in international meetings. Specifically, in this Project we have: 1 – developed for the first time a cognitive task for emotional decision making under ambiguity – the Rodent Gambling Task – that is sensitive to prefrontal and amygdalar functioning just like is observed in the human brain; 2 – demonstrated that prefrontal executive function assessed in our decision-making task is impaired in chronic pain animals, and that this pain-induced impairment is as severe as after a prefrontal lesion; 3 – demonstrated that chronic pain changes the neurochemical balance of dopamine and serotonin in the prefrontal cortex, amygdala, hippocampus, and ventral striatum; 4 – demonstrated that chronic pain impairs working memory without affecting preformance dependent on long-term memory. 5 – demonstrated that chronic pain impairs attentional processing, without affecting choice impulsivity as some authors had previously suggested; 6 – developed a novel software for acquition of behavioral animal data and control of experimental arenas that was freely available for download by the neuroscience community.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Notes:	The final report contains in attachment articles published and/or submitted for publication
Author:	Galhardo, V.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Pain / Cognitive processes / Emotion and motivation / Brain structure and function / Assessment
Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Document

Forebrain pain mechanisms

2009

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Forebrain pain mechanisms

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.07
Location:	Arquivo PCA - Pasta 19/2004
Title:	Forebrain pain mechanisms
Publication year:	2009
URL:	http://www.sciencedirect.com/science/article/pii/S0165017308001537
Abstract/Results:	ABSTRACT: Emotional–affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain areas outside the traditional pain processing network contribute critically to emotional–affective responses and cognitive deficits related to pain. These brain areas include different nuclei of the amygdala and certain prefrontal cortical areas. Their roles in various aspects of pain will be discussed. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Supporting data from preclinical studies in neuropathic pain models will be presented. Neuroimaging analysis provides evidence for plastic changes in the pain processing brain network. Results of clinical studies in neuropathic pain patients suggest that neuroimaging may help determine mechanisms of altered brain functions in pain as well as monitor the effects of pharmacologic interventions to optimize treatment in individual patients. Recent progress in the analysis of higher brain functions emphasizes the concept of pain as a multidimensional experience and the need for integrative approaches to determine the full spectrum of harmful or protective neurobiological changes in pain.
Accessibility:	Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Neugebauer, V.
Secondary author(s):	Galhardo, V., Maione, S., Mackey, S. C.
Document type:	Article
Number of reproductions:	1
Reference:	Neugebauer, V., Galhardo, V., Maione, S., Mackey, S. C. (2009). Forebrain pain mechanisms. Brain Research Reviews, 60(1), 226-242. https://doi.org/10.1016/j.brainresrev.2008.12.014
2-year Impact Factor:	9.432\|2009
Times cited:	272\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Pain / Emotion / Cognition / Decision-making / Amygdala / Prefrontal cortex

Document

Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.08
Location:	Arquivo PCA - Pasta 19/2004
Title:	Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons
Publication year:	2006
URL:	http://www.sciencedirect.com/science/article/pii/S0304394006000231
Abstract/Results:	ABSTRACT: Somatosensory deep dorsal horn spinal neurons were previously shown to present in vitro a bistable state of activity in which a fixed firing rate is maintained over prolonged periods in the absence of stimulation. Those periods of enhanced spinal spontaneous discharge may play a role in the genesis or maintenance of hyperalgesic states, where episodes of durable spontaneous pain are commonly reported. Here we show in vivo that a small percentage of deep spinal neurons (4% of the recorded population) are capable of rapidly shifting between low-frequency and high-frequency levels of spontaneous activity. At least one of the transitions between the two states was induced by stimulation of the receptive field, making this an interesting and unique case in which stable firing rates are switched-on or -off by somatosensory stimuli.
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Monteiro, C.
Secondary author(s):	Lima, D., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Monteiro, C., Lima, D., & Galhardo, V. (2006). Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons. Neuroscience Letters, 398(3), 258-63. https://doi.org/10.1016/j.neulet.2006.01.008
2-year Impact Factor:	2.092\|2006
Times cited:	5\|2025-02-04
Indexed document:	Yes
Quartile:	Q3
Keywords:	Strychnine / Formalin / Pain / Oscillations / Multielectrode extracellular recordings

Document

Recent advances in basic neurosciences and brain disease: from synapses to behavior

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Recent advances in basic neurosciences and brain disease: from synapses to behavior

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.09
Location:	Arquivo PCA - Pasta 19/2004
Title:	Recent advances in basic neurosciences and brain disease: from synapses to behavior
Publication year:	2006
URL:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769477/
Abstract/Results:	ABSTRACT: Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto, Canada on August 21–23, 2006. Unlike other traditional conferences, this new meeting focused on three major aims: (1) to promote new and cutting edge research in neuroscience; (2) to encourage international information exchange and scientific collaborations; and (3) to provide a platform for active scientists to discuss new findings. Up to 64 investigators presented their recent discoveries, from basic synaptic mechanisms to genes related to human brain disease. This meeting was in part sponsored by Molecular Pain, together with University of Toronto (Faculty of Medicine, Department of Physiology as well as Center for the Study of Pain). Our goal for this meeting is to promote future active scientific collaborations and improve human health through fundamental basic neuroscience researches. The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29–31, 2007).
Accessibility:	Document does not exist in file
Language:	eng
Author:	Bi, G.-Q.
Secondary author(s):	Bolshakov, V., Bu, G., Cahill, C., Chen, Z.-F., Collingridge, G., Cooper, R., Coorssen, J. R., El-Husseini, A., Galhardo, V., Gan, W. -B., Gu, J., Inoue, K., Isaac, J., Iwata, K., Jia, Z., Kaang, B. -K., Kawamata, M., Kida, S., Klann, E., Kohno, T., Li, M., Li, X. -J., MacDonald, J., Nader, K., Nguyen, P., Oh, U., Ren, K., Roder, J., Salter, M., Song, W., Sugita, S., Tang, S. -J., Tao, Y., Wang, Y., Woo, N., Woodin, M., Yan, Z., Yoshimura, M., Xu, M., Xu, Z. , Zhang, X., Zhen, M., Zhuo, M.
Document type:	Article
Number of reproductions:	1
Reference:	Bi, G.-Q., Bolshakov, V., Bu, G., Cahill, C., Chen, Z.-F., Collingridge, G., . . . Zhuo, M. (2006). Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain, 2(1), 38-51. https://doi.org/10.1186/1744-8069-2-38
2-year Impact Factor:	4.127\|2007
Impact factor notes:	Impact factor computed since 2007
Times cited:	2\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychophysiology / Pain
Recent advances in basic neurosciences and brain disease: from synapses to behavior

Document

Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

2010

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.10
Location:	Arquivo PCA - Pasta 19/2004
Title:	Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
Publication year:	2010
URL:	http://www.ncbi.nlm.nih.gov/pubmed/20392966
Abstract/Results:	ABSTRACT; Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo, patch-clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Further, pharmacologic inhibition (with a CRF1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting synaptic inhibition was glutamate-driven. The results are consistent with a model of BLA-driven feed-forward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Accessibility:	Document does not exist in file
Language:	eng
Related objects:	PT/FB/BL-2008-126.11
Author:	Ji, G.
Secondary author(s):	Sun, H., Fu, Y., Li, Z., Galhardo, V., Neugebauer, V.
Document type:	Article
Number of reproductions:	1
Reference:	Ji, G., Sun, H., Fu, Y., Li, Z., Galhardo, V., & Neugebauer, V. (2010). Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. Journal of Neuroscience, 30(15), 5451-5464. https://doi.org/10.1523/JNEUROSCI.0225-10.2010
2-year Impact Factor:	7.271\|2010
Times cited:	317\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Amygdala / Prefrontal cortex / Pain / Anxiety / Decision-making / Central sensitization / Synaptic plasticity
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation