| Reference code: | PT/FB/BL-2006-036.08 |
| Location: | Arquivo PCA - Pasta 18/2006
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Title:
| Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients
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| Publication year: | 2012
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URL:
| http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656010&fulltextType=RA&fileId=S0033291711002947
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| Abstract/Results: | ABSTRACT:
BACKGROUND:
The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls.
METHOD:
Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors.
RESULTS:
Patients with childhood maltreatment had higher BMI [25.0 (S.E.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (S.E.=0.6) mg/dl] when compared with healthy controls [23.4 (S.E.=0.4) kg/m2, p=0.030 and 0.2 (S.E.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (S.E.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (S.E.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F 2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue.
CONCLUSIONS:
Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
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| Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Hepgul, N.
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Secondary author(s):
| Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R., Mondelli, V.
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Document type:
| Article
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Number of reproductions:
| 1
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Reference:
| Hepgul, N., Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., . . . Mondelli, V. (2012). Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychological Medicine, 42(9), 1893-1901. https://doi.org/10.1017/S0033291711002947
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| 2-year Impact Factor: | 5.587|2012
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| Times cited: | 84|2025-02-10
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| Indexed document: | Yes
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| Quartile: | Q1
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| Keywords: | Body mass index / Childhood maltreatment / Inflammation / Metabolic syndrome / Psychosis
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