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Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation

2004

BIAL Foundation Archive
- BIAL Grants
  - 2000 Grants
    - 054 - Effect of Galvanic Skin Response (GSR) biofeedback on seizure frequency in patients with poorly controlled epilepsy
      - Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2000
Location:	Arquivo PCA - Pastas 1 a 13/2000
Title:	2000 Grants
Start date:	2001-01 - 2014-02
Dimension/support:	13 caixas de arquivo

Reference code:	PT/FB/BL-2000-054
Location:	Arquivo PCA - Pasta 3/2000
Title:	054 - Effect of Galvanic Skin Response (GSR) biofeedback on seizure frequency in patients with poorly controlled epilepsy
Duration:	2001-05 - 2003-03
Researcher(s):	Yoko Nagai, Michael Trimble, Peter Fenwick, Laura Goldstein, John Lumsden
Institution(s):	Institute of Neurology, University College London (UK)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report Article
Author:	Nagai, Y.
Secondary author(s):	Trimble, M. R., Fenwick, P., Goldstein, L., Lumsden, J.
Number of reproductions:	1
Keywords:	Psychophysiology / Biopsychological problems / Diseases/Injuries / Epilepsy / Intervention

Reference code:	PT/FB/BL-2000-054.03
Location:	Arquivo PCA - Pasta 3/2000
Title:	Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation
Publication year:	2004
URL:	http://www.ncbi.nlm.nih.gov/pubmed/15050551
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=13&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: The contingent negative variation (CNV) is a long-latency electroencephalography (EEG) surface negative potential with cognitive and motor components, observed during response anticipation. CNV is an index of cortical arousal during orienting and attention, yet its functional neuroanatomical basis is poorly understood. We used functional magnetic resonance imaging (fMRI) with simultaneous EEG and recording of galvanic skin response (GSR) to investigate CNV-related central neural activity and its relationship to peripheral autonomic arousal. In a group analysis, blood oxygenation level dependent (BOLD) activity during the period of CNV generation was enhanced in thalamus, somatomotor cortex, bilateral midcingulate, supplementary motor, and insular cortices. Enhancement of CNV-related activity in anterior and midcingulate, SMA, and insular cortices was associated with decreases in peripheral sympathetic arousal. In a subset of subjects in whom we acquired simultaneous EEG and fMRI data, we observed activity in bilateral thalamus, anterior cingulate, and supplementary motor cortex that was modulated by trial-by-trial amplitude of CNV. These findings provide a likely functional neuroanatomical substrate for the CNV and demonstrate modulation of components of this neural circuitry by peripheral autonomic arousal. Moreover, these data suggest a mechanistic model whereby thalamocortical interactions regulate CNV amplitude.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Nagai, Y.
Secondary author(s):	Critchley, H. D. , Featherstone, E., Fenwick, P., Trimble, M. R., Dolan, R. J.
Document type:	Article
Number of reproductions:	1
Reference:	Nagai, Y., Critchley, H. D., Featherstone, E., Fenwick, P., Trimble, M. R.,& Dolan, R. J. (2004). Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation. NeuroImage, 21(4), 1232-1241. https://doi.org/10.1016/j.neuroimage.2003.10.036
2-year Impact Factor:	4.869\|2004
Times cited:	283\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Contingent negative variation (CNV) / Electroencephalography / Blood oxygenation level dependent
Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation