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Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

2016

BIAL Foundation Archive
- BIAL Grants
  - 2012 Grants
    - 217 - Temporal modulation of the subventricular zone neural stem cell niche by choroid plexus-cerebrospinal fluid derived factors
      - Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2012
Location:	SEC PCA
Title:	2012 Grants
Start date:	2013-02

Reference code:	PT/FB/BL-2012-217
Location:	Arquivo PCA - Pasta 27/2012
Title:	217 - Temporal modulation of the subventricular zone neural stem cell niche by choroid plexus-cerebrospinal fluid derived factors
Duration:	2013-08 - 2019-01
Researcher(s):	João Carlos Cruz de Sousa, Fernanda Marques, Joana Palha, Ana Luísa Falcão, Ashley Novais
Institution(s):	ICVS/3B's - Laboratório Associado (ICVS/3B's), Universidade do Minho (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Progress report Final report 6 Articles 1 Master thesis
Language:	eng
Author:	Sousa, J.
Secondary author(s):	Marques, F., Palha, P., Falcão, A., Novais, A.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function

Reference code:	PT/FB/BL-2012-217.10
Location:	Arquivo PCA - Pasta 27/2012
Title:	Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
Publication year:	2016
URL:	https://www.sciencedirect.com/science/article/pii/S0149763416300094
Abstract/Results:	ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is growing along with the increased life expectancy. Although the accumulation and deposition of amyloid beta (Aß) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly understood. Noticeably, increased amyloid load is accompanied by marked inflammatory alterations, both at the level of the brain parenchyma and at the barriers of the brain. However, it is debatable whether the neuroinflammation observed in aging and in AD, together with alterations in the peripheral immune system, are responsible for increased amyloidogenesis, decreased clearance of Aß out of the brain and/or the marked deficits in memory and cognition manifested by AD patients. Herein, we scrutinize some important traits of the pathophysiology of aging and AD, focusing on the interplay between the amyloidogenic pathway, neuroinflammation and the peripheral immune system.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Mesquita, S. D.
Secondary author(s):	Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N., Marques, F.
Document type:	Article
Number of reproductions:	1
Reference:	Mesquita, S. D., Ferreira, A. C., Sousa, J. C., Correia-Neves, M., Sousa, N., & Marques, F. (2016). Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience and Biobehavioral Reviews, 68, 547-562. https://doi.org/10.1016/j.neubiorev.2016.06.014
2-year Impact Factor:	8.299\|2016
Times cited:	114\|2025-02-11
Indexed document:	Yes
Quartile:	Q1
Keywords:	Alzheimer's disease / Aging / Amyloid beta / Cognition / Blood-brain barrier / Choroid plexus / Cerebrospinal fluid / Glial cells / Neurons / Cytokines / Neuroinflammation / Immune system

Document

Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's Disease model mice

2019

BIAL Foundation Archive
- BIAL Grants
  - 2014 Grants
    - 343 - Proteotoxic insults and synaptic dysfunction in the aging brain
      - Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's Disease model mice

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2014
Location:	BF-GMS
Title:	2014 Grants
Start date:	2015-01

Reference code:	PT/FB/BL-2014-343
Location:	BF-GMS
Title:	343 - Proteotoxic insults and synaptic dysfunction in the aging brain
Duration:	2015-06 - 2019-01
Researcher(s):	Cláudio Emanuel Moreira Gomes, Andreas Martin Grabrucker, Joana Margarida Lopes da Silva Cristóvão, Sónia Cristina Alves Dickson Leal Solano
Institution(s):	FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Neurocenter of Ulm University (Germany)
Contents:	Contents: Application form Correspondence Progress report Final report Articles
Author:	Gomes, C.
Secondary author(s):	Grabrucker, A., Cristóvão, J., Solano, S.
Number of reproductions:	1
Keywords:	Protein homeostasis / Brain biometals / Neuroinflammation / Synaptic Biochemistry / Psychophysiology

Reference code:	PT/FB/BL-2014-343.14
Location:	BF-GMS
Title:	Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's Disease model mice
Publication year:	2019
URL:	https://www.frontiersin.org/articles/10.3389/fnins.2019.00640/full
Abstract/Results:	ABSTRACT: Increasing evidence links proteins of the S100 family to the pathogenesis of Alzheimer's disease (AD). S100 proteins are EF-hand calcium-binding proteins with intra- and extracellular functions related to regulation of proliferation, differentiation, apoptosis, and trace metal homeostasis, and are important modulators of inflammatory responses. For example, S100A6, S100A8, and S100B expression levels were found increased in inflammatory diseases, but also neurodegenerative disorders, and S100A8/A9 complexes may provide a mechanistic link between amyloid-beta (A beta) plaque formation and neuroinflammation. On the other hand, S100B, a proinflammatory protein that is chronically up-regulated in AD and whose elevation precedes plaque formation, was recently shown to suppress A beta aggregation. Here, we report expression of S100A6 and S100B in astrocytes and less so in neurons, and low level of expression of S100A8 in both neurons and glial cells in vitro. In vivo, S100A8 expression is almost absent in the brain of aged wildtype mice, while S100A6 and S100B are expressed in all brain regions and most prominently in the cortex and cerebellum. S100B seems to be enriched in Purkinje cells of the cerebellum. In contrast, in the brain of APP23 mice, a mouse model for Alzheimer's disease, S100B, S100A6, and S100A8 show co-localization with A beta plaques, compatible with astrocyte activation, and the expression level of S100A8 is increased in neural cells. While S100A6 and S100B are enriched in the periphery of plaques where less fibrillar is found, S100A8 is more intense within the center of the inclusion. In vitro assays show that, similarly to S100B, S100A6, and S100A8 also delay A beta aggregation suggesting a regulatory action over protein aggregation. We posit that elevated expression levels and overlapping spatial distribution of brain S100 proteins and plaques translates functional relationships between these inflammatory mediators and AD pathophysiology processes that uncover important molecular mechanisms linking the aggregation and neuroinflammation cascades.
Accessibility:	Document exists in file
Language:	eng
Author:	Hagmeyer, S.
Secondary author(s):	Romão, M. A., Cristóvão, J. S., Vilella, A., Zoli, M., Gomes, C. M., Grabrucker, A. M.
Document type:	Article
Number of reproductions:	1
Reference:	Hagmeyer, S., Romão, M. A., Cristóvão, J. S., Vilella, A., Zoli, M., Gomes, C. M., & Grabrucker, A. M. (2019). Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's disease model mice. Frontiers in Neuroscience, 13: 640. https://doi.org/10.3389/fnins.2019.00640
2-year Impact Factor:	3.707\|2019
Times cited:	27\|2025-02-13
Indexed document:	Yes
Quartile:	Q2
Keywords:	S100A8 / S100A6 / S100B / Amyloid beta / Cerebellum / Aggregates / Zinc
Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's Disease model mice